FABP5
FABP5 (fatty acid binding protein 5, also known as E-FABP, PA-FABP and KFABP) is a small intracellular carrier for long-chain fatty acids and related lipids such as endocannabinoids. It was first identified as upregulated in psoriasis tissue and is found in epidermal cells. Browse Assay Genie's current range of FABP5 research reagents below, or read on for the biology behind the target.
FABP5 is an intracellular carrier for long-chain fatty acids and related active lipids, including endocannabinoids, and in doing so it regulates the metabolism and actions of the ligands it binds. Beyond cytosolic transport, it selectively delivers specific fatty acids from the cytosol to the nucleus, where they activate nuclear receptors. It delivers retinoic acid to the nuclear receptor peroxisome proliferator-activated receptor delta, which promotes proliferation and survival.
The FABP5 protein may also act as a synaptic carrier of endocannabinoid at central synapses, thereby controlling retrograde endocannabinoid signalling. It modulates inflammation by regulating PTGES induction through NF-kappa-B activation, and prostaglandin E2 (PGE2) biosynthesis during inflammation. It may also be involved in keratinocyte differentiation. Reported locations include the cytoplasm, nucleus, synapse, postsynaptic density and extracellular space.
The FABP5 gene encodes the fatty acid binding protein of epidermal cells, first identified as upregulated in psoriasis tissue, which explains the former name fatty acid binding protein 5 (psoriasis-associated). It belongs to the calycin superfamily and the FABP family, a group of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands and may contribute to fatty acid uptake, transport and metabolism. Polymorphisms in the gene are associated with type 2 diabetes, and the human genome contains many pseudogenes similar to this locus. Mouse and rat both have an ortholog named Fabp5.
FABP5 carries long-chain fatty acids and related lipids within cells and may contribute to fatty acid uptake, transport and metabolism.
FABP5 may serve as a synaptic carrier of endocannabinoid at central synapses, controlling retrograde endocannabinoid signalling.
FABP5 regulates PTGES induction via NF-kappa-B activation and PGE2 biosynthesis during inflammation.
First identified as upregulated in psoriasis tissue, FABP5 is found in epidermal cells and may be involved in keratinocyte differentiation.
FABP5 is an intracellular carrier for long-chain fatty acids and related lipids such as endocannabinoids. It can deliver specific fatty acids to the nucleus to activate nuclear receptors, and delivers retinoic acid to PPAR delta, promoting proliferation and survival. It also modulates inflammation through PTGES and PGE2.
FABP5 is also called E-FABP, PA-FABP and KFABP. The older HGNC name was fatty acid binding protein 5 (psoriasis-associated), reflecting its first identification as upregulated in psoriasis tissue. UniProt lists the protein as fatty acid-binding protein 5.
FABP5 belongs to the FABP family, small and highly conserved cytoplasmic proteins, and has mouse and rat orthologs named Fabp5. Polymorphisms in the gene are associated with type 2 diabetes, and it was first found upregulated in psoriasis; check the datasheet of any product for its validated reactivity.
Other members of the fatty acid binding protein family with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q01469; product specifications from Assay Genie datasheets.