GAS6
GAS6 (growth arrest specific 6) is a secreted gamma-carboxyglutamic acid (Gla)-containing protein thought to stimulate cell proliferation. It is also known as AXSF and AXLLG, and was previously named AXL receptor tyrosine kinase ligand. Browse Assay Genie's current range of GAS6 research reagents below, or read on for the biology behind the target.
GAS6 is a secreted protein that contains gamma-carboxyglutamic acid (Gla) residues and is thought to be involved in the stimulation of cell proliferation. In the UniProt annotation, its best-characterised mechanistic role concerns infection: GAS6 can bridge phosphatidylserine on the virus envelope to the TAM receptor tyrosine kinase Axl, allowing viral entry by apoptotic mimicry. This route has been described for Dengue virus, Vaccinia virus, ebolavirus and marburgvirus.
The GAS6 gene encodes a protein of the Gla domain containing gene group, which is the HGNC classification for this family. Its orthologues are named Gas6 in both mouse and rat, so the protein can be studied in common rodent models. Researchers working on this protein often search for a GAS6 antibody, a GAS6 ELISA kit or recombinant GAS6 protein to study its expression and signalling.
The earlier name, AXL receptor tyrosine kinase ligand, reflects the interaction with Axl. Other aliases include AXSF. According to the NCBI Gene summary, the GAS6 gene is frequently overexpressed in many cancers and has been implicated as an adverse prognostic marker. Elevated protein levels are also associated with several disease states, including venous thromboembolic disease, systemic lupus erythematosus, chronic renal failure and preeclampsia. These links make GAS6 a point of interest in oncology, vascular biology, autoimmunity and renal and pregnancy-related research.
GAS6 is frequently overexpressed in many cancers and has been implicated as an adverse prognostic marker.
GAS6 can bridge viral envelope phosphatidylserine to Axl, supporting entry of Dengue, Vaccinia, ebolavirus and marburgvirus by apoptotic mimicry.
Elevated GAS6 levels are associated with venous thromboembolic disease, making it a subject of study in thrombosis research.
Raised GAS6 levels accompany systemic lupus erythematosus, chronic renal failure and preeclampsia, supporting biomarker and pathology studies.
GAS6 is a secreted Gla-containing protein thought to be involved in stimulating cell proliferation. It can also bridge phosphatidylserine on virus envelopes to the TAM receptor tyrosine kinase Axl, which allows viral entry by apoptotic mimicry in Dengue, Vaccinia, ebolavirus and marburgvirus.
The HGNC full name is growth arrest specific 6. Aliases and previous symbols include AXSF, FLJ34709, DKFZp666G247 and AXLLG. The gene was previously named AXL receptor tyrosine kinase ligand, reflecting its role as a ligand for the Axl receptor.
GAS6 is frequently overexpressed in many cancers and is an adverse prognostic marker. Elevated levels also occur in venous thromboembolic disease, lupus, chronic renal failure and preeclampsia. Mouse and rat both carry a Gas6 orthologue; check the datasheet of any product for its validated reactivity.
Other growth arrest specific genes and related proteins with research reagents at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q14393; product specifications from Assay Genie datasheets.