HPX
HPX (hemopexin) is a secreted plasma glycoprotein that binds heme with high affinity and carries it to the liver. It is an acute phase protein and a member of the hemopexin family. Browse Assay Genie's current range of HPX research reagents below, or read on for the biology behind the target.
HPX is a heme-binding protein found in the circulation. It binds heme with high affinity and transports it from the plasma to the liver, where the heme is broken down and its iron recovered. Once it has delivered its cargo, free hemopexin returns to the circulation and can be used again. This cycle makes HPX a central component of how the body handles heme once it has been released into plasma.
The HPX gene encodes a plasma glycoprotein that is secreted from the cell. HPX is classed as an acute phase protein, meaning its role is linked to the response to physiological stress. The NCBI Gene summary also notes that the encoded protein may be involved in protecting cells from oxidative stress. Researchers studying the HPX gene or the hemopexin protein are often interested in this connection between heme handling and cellular protection.
The protein belongs to the hemopexin family. Orthologues of the gene are present in mouse and rat, both named Hpx, which allows the heme-transport function to be explored in common laboratory models. Studies of hemopexin typically draw on HPX antibody and HPX ELISA kit approaches, as well as work with purified HPX protein, to examine its abundance, binding behaviour and role in heme and iron biology.
HPX binds heme in plasma and carries it to the liver, making it a key protein for studying heme clearance.
After delivery to the liver, heme is broken down and iron recovered, linking hemopexin to iron handling.
HPX may protect cells from oxidative stress, so it is relevant to studies of cellular defence.
As an acute phase plasma protein, HPX is of interest in work on the body's response to physiological stress.
HPX binds heme with high affinity in plasma and transports it to the liver for breakdown and iron recovery. The free hemopexin then returns to the circulation. It is an acute phase protein and may help protect cells from oxidative stress.
HGNC lists the approved symbol HPX for hemopexin, with no alternative aliases or previous symbols recorded. It is a secreted plasma glycoprotein, so it is found in the circulation rather than being retained inside cells.
Yes. Mouse and rat both have an orthologous gene named Hpx, and the protein belongs to the hemopexin family. Researchers can therefore study heme transport in rodent models; check the datasheet of any product for its validated reactivity.
Other heme, iron-metabolism and acute phase protein targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P02790; product specifications from Assay Genie datasheets.