Iba1
Iba1, encoded by the AIF1 gene and also known as allograft inflammatory factor 1, AIF-1 and IRT-1, is a calcium-binding, actin-binding protein. It enhances membrane ruffling and RAC activation and is linked to macrophage function and vascular inflammation. Browse Assay Genie's current range of Iba1 research reagents below, or read on for the biology behind the target.
Iba1 is an actin-binding protein that enhances membrane ruffling and RAC activation. It also enhances the actin-bundling activity of LCP1 and binds calcium. Through these activities it contributes to RAC signalling and to phagocytosis, and it may play a role in macrophage activation and function.
In the cell, Iba1 is found in the cytoskeleton, at the ruffle membrane and at the phagocytic cup, which fits its role in actin remodelling and particle uptake. The AIF1 gene belongs to the HGNC group of EF-hand domain containing genes, a group defined by calcium-binding motifs. Researchers often work with the Iba1 protein and the AIF1 gene in studies of macrophage biology, and Iba1 antibody and Iba1 ELISA kit reagents are common tools for that work. The mouse and rat orthologues are both named Aif1.
The gene is induced by cytokines and interferon. Iba1 promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes, enhances lymphocyte migration, and plays a role in vascular inflammation. The name allograft inflammatory factor 1 reflects this inflammatory context, and IBA1 and AIF-1 are alternative designations for the same protein. According to NCBI Gene, polymorphisms in AIF1 may be associated with systemic sclerosis. Alternative splicing produces multiple transcript variants, although the full-length and coding nature of some of them is not certain.
Iba1 may play a role in macrophage activation and function, making it a relevant protein for studying macrophage responses.
Iba1 enhances membrane ruffling, RAC activation and LCP1 actin bundling, so it is useful for cytoskeletal dynamics research.
Iba1 localises to the phagocytic cup and plays a role in phagocytosis, linking actin remodelling to particle uptake.
Iba1 promotes vascular smooth muscle cell proliferation and plays a role in vascular inflammation and T-lymphocyte growth and migration.
Iba1 is an actin-binding protein that binds calcium and enhances membrane ruffling and RAC activation. It enhances LCP1 actin bundling, plays a role in phagocytosis, and may contribute to macrophage activation. It also promotes proliferation of vascular smooth muscle cells and T-lymphocytes.
Iba1 is encoded by AIF1, and its full name is allograft inflammatory factor 1. Aliases include AIF-1, IRT-1 and IBA1. NCBI Gene notes that alternative splicing gives multiple transcript variants, though the coding nature of some is uncertain.
Mouse and rat both carry an orthologous gene named Aif1; check the datasheet of any product for its validated reactivity. NCBI Gene reports that polymorphisms in AIF1 may be associated with systemic sclerosis, and UniProt notes a role in vascular inflammation.
Related targets with products at Assay Genie, including another protein sharing the AIF name.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P55008; product specifications from Assay Genie datasheets.