IGFBP-6
IGFBP-6 (insulin-like growth factor-binding protein 6) is a secreted member of the insulin-like growth factor binding protein group. It binds IGFs, prolongs their half-life and alters how they interact with cell surface receptors, and it also activates MAPK signalling and promotes cell migration. Browse Assay Genie's current range of IGFBP-6 research reagents below, or read on for the biology behind the target.
IGFBP-6 belongs to the insulin-like growth factor binding proteins, which prolong the half-life of the IGFs and alter the way IGFs interact with their cell surface receptors. In cell culture, IGF-binding proteins have been shown to either inhibit or stimulate the growth-promoting effects of the IGFs, so the outcome depends on context. IGFBP-6 is annotated as having insulin-like growth factor II binding activity, and it forms part of the insulin-like growth factor binary complex.
Beyond its role as an IGF carrier and modulator, IGFBP-6 is reported to activate the MAPK signalling pathway and to induce cell migration. NCBI Gene annotation likewise links the protein to cell migration and to positive regulation of the stress-activated MAPK cascade. It also has identical protein binding activity. These features make the IGFBP-6 protein a useful subject for studies of IGF availability and of IGF-independent signalling.
The IGFBP6 gene encodes a secreted protein, and mouse and rat each carry an Igfbp6 ortholog, which allows comparative work in common model organisms. IGFBP-6 has been implicated in obesity. It has also been described as a biomarker of breast cancer, in situ carcinoma, leiomyoma and neovascular inflammatory vitreoretinopathy. Researchers measuring IGFBP-6 often study it alongside other IGFBP family members to separate shared and distinct actions within the IGF axis.
IGFBP-6 binds IGF-II, prolongs IGF half-life and alters IGF interaction with cell surface receptors, making it central to studies of IGF regulation.
IGFBP-6 induces cell migration and is involved in positive regulation of the stress-activated MAPK cascade, so it is relevant to migration and signalling research.
IGFBP-6 is described as a biomarker of breast cancer and in situ carcinoma, as well as leiomyoma.
IGFBP-6 has been implicated in obesity and noted as a biomarker of neovascular inflammatory vitreoretinopathy.
IGFBP-6 binds insulin-like growth factors, prolongs their half-life and alters their interaction with cell surface receptors. IGF-binding proteins can inhibit or stimulate IGF-driven growth in cell culture. IGFBP-6 also activates the MAPK signalling pathway and induces cell migration.
The official gene symbol is IGFBP6, and the HGNC full name is insulin like growth factor binding protein 6. No other aliases or previous symbols are recorded. The UniProt entry is named insulin-like growth factor-binding protein 6, and the protein is secreted.
Yes. Mouse and rat each have an ortholog named Igfbp6, so the protein can be studied in standard rodent models. Reactivity differs between reagents, so check the datasheet of any product for its validated reactivity.
Other members of the insulin-like growth factor binding protein group, for comparing IGF-axis regulators.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P24592; product specifications from Assay Genie datasheets.