IL-24
IL-24 (interleukin 24, also known as mda-7, IL10B, Mob-5, C49A, FISP and ST16) is a secreted, multifunctional cytokine of the IL-10 family. It is produced mainly by T-cells and regulates immune response, tissue homeostasis, host defence and oncogenesis. Browse Assay Genie's current range of IL-24 research reagents below, or read on for the biology behind the target.
IL-24 is a multifunctional cytokine mainly produced by T-cells. It signals through two receptor complexes, IL20RA/IL20RB and IL20RB/IL22RA1, and in turn stimulates the JAK1-STAT3 and MAPK pathways. It promotes the secretion of pro-inflammatory mediators including IL8 and MMP1. It also has antiviral functions and induces the type I interferon response during influenza infection.
Inside the cell, IL-24 helps maintain endoplasmic reticulum homeostasis by restricting the eIF2alpha-CHOP pathway-mediated stress signal. It also acts as a quality control mechanism for the ubiquitin proteasome system, alerting the cell to proteasome dysfunction through activation of PKR/EIF2AK2. The IL24 gene encodes a member of the IL-10 family of cytokines, and orthologues are present in mouse and rat (both Il24). Alternatively spliced transcript variants encoding distinct isoforms have been reported.
The gene was first identified as one induced during terminal differentiation in melanoma cells, which gave rise to the name mda-7. The IL-24 protein can induce apoptosis selectively in various cancer cells. Overexpression of the gene leads to elevated expression of several GADD family genes, which correlates with apoptosis. In melanoma cells, but not in normal immortalised melanocytes, it induces phosphorylation of p38 MAPK and of the heat shock protein HSP27. These properties make IL-24 a frequent subject in cancer biology and immunology research.
IL-24 induces apoptosis selectively in various cancer cells and was identified as a gene induced during terminal differentiation in melanoma cells.
Produced mainly by T-cells, IL-24 plays a regulatory role in immune response, tissue homeostasis and host defence.
IL-24 has antiviral functions and induces the type I interferon response during influenza infection.
IL-24 restricts eIF2alpha-CHOP stress signalling in the endoplasmic reticulum and alerts cells to proteasome dysfunction via PKR/EIF2AK2.
IL-24 is a multifunctional cytokine that regulates immune response, tissue homeostasis, host defence and oncogenesis. It signals through IL20RA/IL20RB or IL20RB/IL22RA1 receptor complexes, activating JAK1-STAT3 and MAPK pathways, and promotes release of mediators such as IL8 and MMP1.
IL-24 is also known as mda-7 (melanoma differentiation-associated gene 7), IL10B, Mob-5, C49A, FISP and ST16. The mda-7 name reflects its discovery as a gene induced during terminal differentiation in melanoma cells. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Mouse and rat both carry an Il24 orthologue; check the datasheet of any product for its validated reactivity. IL-24 belongs to the IL-10 family and can induce apoptosis selectively in various cancer cells, with overexpression raising several GADD family genes.
Other IL-10 family cytokines and related interleukins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q13007; product specifications from Assay Genie datasheets.