IL-34
IL-34 (interleukin 34) is a secreted cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. It is encoded by the IL34 gene, previously known as C16orf77 or MGC34647, and signals through the colony-stimulating factor-1 receptor. Browse Assay Genie's current range of IL-34 research reagents below, or read on for the biology behind the target.
IL-34 is a cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. It acts through the colony-stimulating factor-1 receptor (CSF1R), and signalling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 and MAPK3/ERK1. IL-34 also promotes the release of pro-inflammatory chemokines, and so plays an important role in innate immunity and in inflammatory processes.
In bone biology, IL-34 contributes to the regulation of osteoclast proliferation and differentiation, and to the regulation of bone resorption. These activities place the cytokine at the interface between myeloid cell biology, inflammation and skeletal homeostasis, which makes the IL-34 protein a frequent subject in studies of macrophage and osteoclast function.
The human IL34 gene encodes a secreted protein that belongs to the IL-34 family and is classed by HGNC within the interleukins gene group. The gene was formerly designated chromosome 16 open reading frame 77 (C16orf77), with MGC34647 also recorded as a previous symbol. Orthologous Il34 genes are annotated in both mouse and rat, allowing the cytokine to be studied in common rodent models.
IL-34 promotes the differentiation, survival and proliferation of monocytes and macrophages through CSF1R, making it a key cytokine for myeloid cell studies.
IL-34 promotes the release of pro-inflammatory chemokines and plays an important role in innate immunity and inflammatory processes.
IL-34 regulates osteoclast proliferation and differentiation as well as bone resorption, linking the cytokine to skeletal biology.
Signalling through CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 and MAPK3/ERK1, a readout used in pathway studies.
IL-34 is a cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. It signals through CSF1R, stimulates ERK1/ERK2 phosphorylation, promotes release of pro-inflammatory chemokines and helps regulate osteoclast differentiation and bone resorption.
The HGNC-approved name is interleukin 34, with the symbol IL34. Earlier designations include C16orf77 (chromosome 16 open reading frame 77) and MGC34647. UniProt lists the protein as Interleukin-34 and places it in the IL-34 family of secreted cytokines.
Yes. Orthologous Il34 genes are annotated in both mouse and rat, so the cytokine can be investigated in rodent models as well as in human systems. Please check the datasheet of any product for its validated reactivity.
Other interleukins and cytokines involved in inflammation and immune signalling, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q6ZMJ4; product specifications from Assay Genie datasheets.