Lymphotoxin
Lymphotoxin (LTA, lymphotoxin-alpha, TNFSF1, LT, TNFB) is a cytokine of the tumour necrosis factor family, produced by lymphocytes. It signals through TNF receptor family members and contributes to inflammatory, immunostimulatory and antiviral responses. Browse Assay Genie's current range of Lymphotoxin research reagents below, or read on for the biology behind the target.
Lymphotoxin is a cytokine produced by lymphocytes and is highly inducible. In its homotrimeric form it binds TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with lymphotoxin-beta (LTB) it binds TNFRSF3/LTBR. The heterotrimers anchor lymphotoxin-alpha to the cell surface, whereas the protein is otherwise secreted, which is why both secreted and membrane locations are recorded. Lymphotoxin is cytotoxic for a wide range of tumour cells in vitro and in vivo.
The LTA gene encodes the lymphotoxin-alpha protein, a member of the tumour necrosis factor family. Alternatively spliced transcript variants have been observed for the gene. Mouse and rat orthologs are both named Lta, so the lymphotoxin gene can be studied in common rodent models. The protein mediates a large variety of inflammatory, immunostimulatory and antiviral responses, takes part in apoptosis, and is involved in the formation of secondary lymphoid organs during development.
The gene has gone by several names, including TNFSF1, LT and TNFB, and was formerly listed as lymphotoxin alpha (TNF superfamily, member 1). Genetic variations in the gene are associated with susceptibility to leprosy type 4, myocardial infarction, non-Hodgkin's lymphoma and psoriatic arthritis. Researchers working on lymphotoxin therefore tend to combine immunology, cell death and disease-association questions, often alongside other TNF superfamily ligands and receptors.
Lymphotoxin mediates a large variety of inflammatory, immunostimulatory and antiviral responses, making it a focus for studies of cytokine-driven immune activity.
Lymphotoxin is involved in the formation of secondary lymphoid organs during development, linking it to studies of lymphoid tissue organisation.
Lymphotoxin plays a role in apoptosis and is cytotoxic for a wide range of tumour cells in vitro and in vivo.
Variants in the gene are associated with leprosy type 4, myocardial infarction, non-Hodgkin's lymphoma and psoriatic arthritis, supporting genetic and translational research.
Lymphotoxin is a cytokine produced by lymphocytes. As a homotrimer it binds TNFR1, TNFBR and HVEM; with LTB it forms heterotrimers that bind LTBR. It mediates inflammatory, immunostimulatory and antiviral responses, contributes to secondary lymphoid organ formation and plays a role in apoptosis.
Lymphotoxin is encoded by LTA and is also called lymphotoxin-alpha, TNFSF1, LT and TNFB. An earlier HGNC name was lymphotoxin alpha (TNF superfamily, member 1). NCBI notes that alternatively spliced transcript variants have been observed for the gene.
Genetic variations in LTA are associated with susceptibility to leprosy type 4, myocardial infarction, non-Hodgkin's lymphoma and psoriatic arthritis. Mouse and rat both have an ortholog named Lta; check the datasheet of any product for its validated reactivity.
Related targets with products at Assay Genie, for researchers working on lymphotoxin and neighbouring pathways.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P01374; product specifications from Assay Genie datasheets.