MIP-1 beta
MIP-1 beta (C-C motif chemokine ligand 4, encoded by CCL4) is a secreted monokine with inflammatory and chemokinetic properties. It is also known as MIP-1-beta, Act-2, AT744.1, LAG1 and SCYA4, and is one of the major HIV-suppressive factors produced by CD8+ T-cells. Browse Assay Genie's current range of MIP-1 beta research reagents below, or read on for the biology behind the target.
MIP-1 beta is a monokine with inflammatory and chemokinetic properties. It binds to the chemokine receptor CCR5. The protein is secreted, and the NCBI Gene summary describes it as mitogen-inducible, with chemokinetic and inflammatory functions.
MIP-1 beta is one of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2 and simian immunodeficiency virus (SIV). A processed form, MIP-1-beta(3-69), keeps the ability to down-modulate surface expression of CCR5 and to inhibit CCR5-mediated entry of HIV-1 into T-cells. This processed form is also a ligand for CCR1 and for CCR2 isoform B, which makes MIP-1 beta a useful reference point when studying how a single chemokine can act through several receptors.
The CCL4 gene belongs to the HGNC group of chemokine ligands, and the protein belongs to the intercrine beta (chemokine CC) family. Earlier names include small inducible cytokine A4 (homologous to mouse Mip-1b) and chemokine (C-C motif) ligand 4, reflected in the SCYA4 alias. Mouse and rat each have a Ccl4 ortholog, so MIP-1 beta can be studied in common rodent models as well as in human systems.
MIP-1 beta binds CCR5, and its processed form also acts on CCR1 and CCR2 isoform B, making it relevant to receptor pharmacology.
As a major HIV-suppressive factor from CD8+ T-cells, MIP-1 beta is studied for inhibition of HIV-1, HIV-2 and SIV.
The protein has inflammatory and chemokinetic functions, so it is a common readout in studies of immune cell activation and migration.
MIP-1-beta(3-69) down-modulates surface CCR5 and blocks CCR5-mediated HIV-1 entry into T-cells, supporting work on receptor regulation.
MIP-1 beta is a secreted monokine with inflammatory and chemokinetic properties. It binds CCR5 and is one of the major HIV-suppressive factors produced by CD8+ T-cells. Its processed form, MIP-1-beta(3-69), also binds CCR1 and CCR2 isoform B.
The gene symbol is CCL4, for C-C motif chemokine ligand 4. Aliases include MIP-1-beta, Act-2, AT744.1, LAG1 and SCYA4. Previous names are small inducible cytokine A4 (homologous to mouse Mip-1b) and chemokine (C-C motif) ligand 4.
Yes. Both mouse and rat have a Ccl4 ortholog of the human CCL4 gene. The protein belongs to the intercrine beta (chemokine CC) family. Check the datasheet of any product for its validated reactivity.
Other CC chemokine ligands and related immune signalling targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P13236; product specifications from Assay Genie datasheets.