NKp46
NKp46 (natural cytotoxicity triggering receptor 1, encoded by NCR1) is a cytotoxicity-activating receptor of the natural cytotoxicity receptor family. It is also known as NK-p46, CD335 and LY94. Browse Assay Genie's current range of NKp46 research reagents below, or read on for the biology behind the target.
NKp46 is a cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells in mediating tumour cell lysis. It belongs to the natural cytotoxicity receptor (NCR) family and is localised to the cell membrane, where it acts as an immune receptor on the cell surface. Gene Ontology-based predictions describe it as having immune receptor activity and transmembrane signalling receptor activity.
The protein is encoded by the NCR1 gene, and the NKp46 protein is classed by HGNC within the CD molecules and the immunoglobulin-like domain containing gene groups, which accounts for its designation CD335. Predicted roles in the NCBI Gene summary include involvement in defence response to virus and detection of virus, as well as an immune response-inhibiting cell surface receptor signalling pathway. The same summary lists a predicted association with the SWI/SNF complex and activity at the plasma membrane. Mouse and rat both carry an orthologous Ncr1 gene.
NKp46 has appeared under several names. The current HGNC name, natural cytotoxicity triggering receptor 1, replaced the earlier lymphocyte antigen 94 (mouse) homolog, described as an activating NK-receptor, which gave rise to the aliases LY94 and NK-p46. NCBI Gene lists NCR1 as a biomarker in acquired immunodeficiency syndrome, anogenital venereal wart, hepatitis C and lymphoproliferative syndrome. A related family member, NCR2, is also studied in NK cell biology.
NKp46 is a cytotoxicity-activating receptor on natural killer cells, making it a focus for studying how activated NK cells are triggered.
The receptor may contribute to the efficiency of activated NK cells in lysing tumour cells, which is relevant to anti-tumour immune research.
NCR1 is predicted to act in defence response to virus and detection of virus, supporting studies of innate antiviral recognition.
NCBI Gene reports NCR1 as a biomarker in hepatitis C, AIDS, anogenital venereal wart and lymphoproliferative syndrome.
NKp46 is a cytotoxicity-activating receptor on the cell membrane. It may contribute to the increased efficiency of activated natural killer cells in mediating tumour cell lysis. It belongs to the natural cytotoxicity receptor family and is predicted to have immune receptor and transmembrane signalling receptor activity.
The NKp46 gene symbol is NCR1, and the full name is natural cytotoxicity triggering receptor 1. Aliases include NK-p46, NKP46, CD335 and LY94. The older name was lymphocyte antigen 94 (mouse) homolog, described as an activating NK-receptor.
Yes. Mouse and rat each have an orthologous gene named Ncr1. This allows the receptor to be studied in rodent models, although you should check the datasheet of any product for its validated reactivity.
Other natural cytotoxicity receptors and NK cell markers with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O76036; product specifications from Assay Genie datasheets.