OX40
OX40, encoded by the TNFRSF4 gene and also known as CD134, ACT35 and TXGP1L, is a membrane receptor of the tumour necrosis factor receptor superfamily. It activates NF-kappaB signalling and has been linked to T cell responses and the suppression of apoptosis. Browse Assay Genie's current range of OX40 research reagents below, or read on for the biology behind the target.
OX40 is a member of the TNF-receptor superfamily. The receptor has been shown to activate NF-kappaB through its interaction with the adaptor proteins TRAF2 and TRAF5. This places OX40 in a signalling route that links receptor engagement at the cell membrane to transcriptional responses.
Knockout studies in mice suggest that OX40 promotes the expression of the apoptosis inhibitors BCL2 and BCL2L1 (BCL-XL), and so suppresses apoptosis. The same studies point to roles for the receptor in the CD4+ T cell response and in T cell-dependent B cell proliferation and differentiation. These findings make OX40 a frequent subject in immunology research, where its function is examined in the context of T cell survival and help for B cells.
The human OX40 gene is TNFRSF4, and the protein is annotated in UniProt as tumour necrosis factor receptor superfamily member 4. HGNC lists it within the CD molecules and the tumour necrosis factor receptor superfamily, and it is also known as CD134, ACT35 and TXGP1L. Mouse and rat both carry a Tnfrsf4 ortholog, which supports comparative work in rodent models. In addition to its role in immune signalling, OX40 acts as a receptor for human herpesvirus 6B (HHV-6B) in the context of microbial infection, which makes it relevant to studies of viral entry.
OX40 is implicated in the CD4+ T cell response, making it a target for studies of T cell activation and survival.
Knockout studies suggest OX40 contributes to T cell-dependent B cell proliferation and differentiation.
OX40 activates NF-kappaB through TRAF2 and TRAF5, so it is used to study TNF receptor superfamily signal transduction.
OX40 supports expression of BCL2 and BCL-XL in mouse studies and serves as a receptor for HHV-6B.
OX40 is a TNF-receptor superfamily member that activates NF-kappaB through the adaptor proteins TRAF2 and TRAF5. Mouse knockout studies suggest it promotes BCL2 and BCL-XL expression, suppresses apoptosis, and contributes to CD4+ T cell responses and T cell-dependent B cell proliferation and differentiation.
OX40 is the gene product of TNFRSF4, whose full name is TNF receptor superfamily member 4. Aliases include CD134, ACT35 and TXGP1L. The previous HGNC name was tumour necrosis factor receptor superfamily, member 4. These names all refer to the same receptor, so use them when searching the literature.
Yes. Both mouse and rat have an ortholog named Tnfrsf4, and mouse knockout studies have informed much of what is known about OX40 function. Human OX40 also acts as a receptor for HHV-6B. Check the datasheet of any product for its validated reactivity.
Other TNF receptor superfamily members with products at Assay Genie, for researchers studying related receptor signalling.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P43489; product specifications from Assay Genie datasheets.