PECAM-1
PECAM-1 (platelet and endothelial cell adhesion molecule 1), also known as CD31, is an immunoglobulin superfamily protein found on blood cells and at endothelial cell junctions. It is likely involved in leukocyte migration, angiogenesis and integrin activation. Browse Assay Genie's current range of PECAM-1 research reagents below, or read on for the biology behind the target.
PECAM-1 is a cell adhesion molecule of the immunoglobulin superfamily. According to the NCBI Gene summary, the protein is found on the surface of platelets, monocytes, neutrophils and some types of T-cells, and it makes up a large portion of endothelial cell intercellular junctions. It is likely involved in leukocyte migration, angiogenesis and integrin activation. UniProt additionally annotates that PECAM-1 does not protect against apoptosis.
In UniProt, PECAM-1 is localised to the cell membrane, where it is associated with membrane rafts and cell junctions, consistent with its role at sites of cell-cell contact. The human PECAM1 gene encodes the protein under UniProt entry P16284, and the mouse and rat orthologs are both named Pecam1. HGNC classifies it within the CD molecules, the immunoglobulin-like domain containing group and the Ig-like cell adhesion molecule family.
The protein is widely referred to by its cluster of differentiation designation, CD31, which is the symbol listed as an alias for the gene. An earlier approved name was platelet/endothelial cell adhesion molecule 1. Because it is present on both endothelial and several haematopoietic cell types, PECAM-1 is a useful target for studying endothelial junction biology, vascular development and leukocyte trafficking.
PECAM-1 is likely involved in leukocyte migration, making it a relevant target for studying how immune cells interact with endothelial cell junctions.
The protein is likely involved in angiogenesis, so PECAM-1 is studied in work on endothelial cell behaviour and the formation of new vessels.
PECAM-1 makes up a large portion of endothelial cell intercellular junctions, placing it at the centre of studies on junction organisation.
PECAM-1 is likely involved in integrin activation, linking it to research on adhesion signalling in platelets and leukocytes.
PECAM-1 is an immunoglobulin superfamily adhesion molecule that makes up a large portion of endothelial cell intercellular junctions. It is likely involved in leukocyte migration, angiogenesis and integrin activation. UniProt notes that it does not protect against apoptosis.
Yes. CD31 is a listed alias of the PECAM1 gene, and the protein is classed among the CD molecules by HGNC. The previously used name was platelet/endothelial cell adhesion molecule 1. All of these names refer to the same protein, UniProt P16284.
PECAM-1 is found on platelets, monocytes, neutrophils and some T-cells, and at endothelial cell junctions. Mouse and rat both have a Pecam1 ortholog, so rodent models can be used; check the datasheet of any product for its validated reactivity.
Other adhesion molecules, endothelial markers and integrin-pathway targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P16284; product specifications from Assay Genie datasheets.