Periostin
Periostin (POSTN, also known as OSF-2 and PN) is a secreted extracellular matrix protein that promotes cell attachment and spreading. It contributes to tissue development and regeneration, including wound healing and ventricular remodelling after myocardial infarction. Browse Assay Genie's current range of Periostin research reagents below, or read on for the biology behind the target.
Periostin induces cell attachment and spreading and plays a role in cell adhesion. It binds to integrins, which supports the adhesion and migration of epithelial cells. Periostin also enhances the incorporation of BMP1 into the fibronectin matrix of connective tissues, which in turn supports the proteolytic activation of lysyl oxidase (LOX). In this way it links cell adhesion to the organisation and maturation of the extracellular matrix.
The POSTN gene encodes a secreted extracellular matrix protein. UniProt records its subcellular location as the Golgi apparatus and as secreted protein in the extracellular space and extracellular matrix. HGNC places the gene in the Gla domain containing group. Alternative splicing of the periostin gene produces multiple transcript variants that encode different isoforms. The mouse ortholog is Postn.
The gene was previously named osteoblast specific factor, and OSF-2 and PN remain in use as aliases. Periostin functions in tissue development and regeneration, including wound healing and ventricular remodelling following myocardial infarction. It also plays a role in cancer stem cell maintenance and metastasis. Mice lacking the gene show cardiac valve disease and skeletal and dental defects, which points to roles in the development of these tissues.
Periostin functions in ventricular remodelling after myocardial infarction, and loss of the gene in mice causes cardiac valve disease.
As a secreted matrix protein, periostin supports tissue development and regeneration, including wound healing.
Periostin plays a role in cancer stem cell maintenance and metastasis, making it a subject of tumour biology studies.
Periostin binds integrins, drives cell attachment and spreading, and promotes BMP1 incorporation into the fibronectin matrix for LOX activation.
Periostin is a secreted extracellular matrix protein that induces cell attachment and spreading. It binds integrins to support epithelial cell adhesion and migration, and it enhances BMP1 incorporation into the fibronectin matrix, which supports proteolytic activation of lysyl oxidase (LOX).
The HGNC symbol is POSTN, and aliases include OSF-2 and PN. The gene was previously called osteoblast specific factor. Alternative splicing of the gene produces multiple transcript variants that encode different periostin isoforms.
Periostin has a mouse ortholog, Postn. Mice lacking it show cardiac valve disease and skeletal and dental defects. The human protein is linked to ventricular remodelling after myocardial infarction and to cancer stem cell maintenance and metastasis. Check the datasheet of any product for its validated reactivity.
Matrix proteins, integrin partners and remodelling enzymes that act alongside periostin in cell adhesion and tissue repair.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q15063; product specifications from Assay Genie datasheets.