S100A11
S100A11 (S100 calcium binding protein A11, also known as S100C or calgizzarin) is a member of the S100 family of EF-hand calcium-binding proteins. It facilitates the differentiation and cornification of keratinocytes and is found in the cytoplasm and nucleus. Browse Assay Genie's current range of S100A11 research reagents below, or read on for the biology behind the target.
S100A11 is a small calcium-binding protein that belongs to the S100 family. Like other family members, it contains two EF-hand calcium-binding motifs. Its annotated function is to facilitate the differentiation and cornification of keratinocytes. The NCBI Gene summary adds that the protein may function in motility, invasion and tubulin polymerisation.
S100 proteins are localised in the cytoplasm and/or nucleus of a wide range of cells, where they are involved in regulating cellular processes such as cell cycle progression and differentiation. S100A11 is reported in the cytoplasm and nucleus. The S100A11 gene sits within a cluster of S100 genes on chromosome 1q21; the S100 gene family includes at least 13 members in this cluster. HGNC classifies it within the S100 calcium binding proteins and EF-hand domain containing gene groups.
The protein was previously named S100 calcium-binding protein A11 (calgizzarin), and the symbol S100C is an earlier alias. Chromosomal rearrangements and altered expression of the S100A11 gene have been implicated in tumour metastasis, which makes it a topic of interest in studies of cell motility and invasion. Orthologues are annotated in mouse and rat, both named S100a11, so comparative work in rodent models is possible.
S100A11 facilitates the differentiation and cornification of keratinocytes, making it relevant to studies of epidermal biology.
Chromosomal rearrangements and altered expression of S100A11 have been implicated in tumour metastasis.
S100A11 may function in motility and invasion, so it is studied in work on how cells migrate.
The protein may take part in tubulin polymerisation, linking calcium-binding S100 proteins to cytoskeletal dynamics.
S100A11 facilitates the differentiation and cornification of keratinocytes. The NCBI Gene summary also notes that it may function in motility, invasion and tubulin polymerisation. As an S100 protein, it binds calcium through EF-hand motifs and is involved in processes such as cell cycle progression and differentiation.
The HGNC name is S100 calcium binding protein A11. The alias S100C is also used, and the previous name was S100 calcium-binding protein A11 (calgizzarin). UniProt lists the protein as Protein S100-A11. Searching under any of these names should help you find the same target.
Chromosomal rearrangements and altered expression of the S100A11 gene have been implicated in tumour metastasis. Orthologues named S100a11 are annotated in both mouse and rat. Check the datasheet of any product for its validated reactivity.
Other S100 family calcium-binding proteins and EF-hand proteins studied in differentiation, motility and tumour biology.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P31949; product specifications from Assay Genie datasheets.