TROP-2
TROP-2 (tumour-associated calcium signal transducer 2, encoded by TACSTD2) is a membrane protein of the EPCAM family. It is a carcinoma-associated antigen and cell surface receptor that transduces calcium signals, also known as TROP2, GA733-1, EGP-1 and M1S1. Browse Assay Genie's current range of TROP-2 research reagents below, or read on for the biology behind the target.
TROP-2 is a cell surface receptor that transduces calcium signals. It is described as a carcinoma-associated antigen, and UniProt notes that it may function as a growth factor receptor. As a membrane protein, it sits at the interface between the cell and its environment, which makes it a useful subject for studies of receptor signalling and of antigens associated with carcinoma.
The human TACSTD2 gene is intronless and encodes the TROP-2 protein, which belongs to the EPCAM family. Mouse and rat each carry a Tacstd2 ortholog, so the target can be studied in common rodent models. Researchers working with the TROP-2 protein or the TACSTD2 gene will find the identifiers in the facts panel on this page.
The protein has accumulated several names over time. HGNC lists TROP2, GA733-1, EGP-1 and M1S1 as aliases or previous symbols, and the previous gene name was membrane component chromosome 1 surface marker 1. Mutations in the gene have been associated with gelatinous drop-like corneal dystrophy, linking TROP-2 to corneal biology as well as to its better-known role as a carcinoma-associated antigen. Whether you are designing a TROP-2 antibody or TROP-2 ELISA kit experiment, the sourced biology above frames the main questions: where the protein is found, how it signals, and what happens when the gene is mutated.
TROP-2 is a carcinoma-associated antigen, so it is studied as a cell surface marker in carcinoma research.
As a cell surface receptor that transduces calcium signals, TROP-2 is relevant to studies of signal transduction at the membrane.
UniProt proposes that TROP-2 may function as a growth factor receptor, prompting work on its receptor role.
Mutations in TACSTD2 are associated with gelatinous drop-like corneal dystrophy, making the gene relevant to inherited eye disease studies.
TROP-2 is a cell surface receptor that transduces calcium signals. UniProt also notes that it may function as a growth factor receptor. It is described as a carcinoma-associated antigen and belongs to the EPCAM family of membrane proteins.
The gene symbol is TACSTD2, and aliases include TROP2, GA733-1, EGP-1 and M1S1. The HGNC full name is tumour associated calcium signal transducer 2, and a previous name was membrane component chromosome 1 surface marker 1.
Mutations in TACSTD2 have been associated with gelatinous drop-like corneal dystrophy. Orthologs named Tacstd2 exist in mouse and rat. Check the datasheet of any product for its validated reactivity.
Other EPCAM-family members, carcinoma-associated antigens and calcium signalling targets are listed where Assay Genie has a page for them.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P09758; product specifications from Assay Genie datasheets.