TUBG1
TUBG1 (tubulin gamma 1, also known as TUBG or TUBGCP1) is a member of the tubulin family and a core component of the gamma-tubulin ring complex. It mediates microtubule nucleation at the centrosome and is required for microtubule formation and cell cycle progression. Browse Assay Genie's current range of TUBG1 research reagents below, or read on for the biology behind the target.
Tubulin is the major constituent of microtubules, protein filaments built from alpha- and beta-tubulin heterodimers. TUBG1 encodes gamma-tubulin, a key component of the gamma-tubulin ring complex (gTuRC), which mediates microtubule nucleation. The gTuRC regulates minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protofilaments, a critical step in centrosome duplication and spindle formation.
The TUBG1 protein belongs to the tubulin family and localises to the centrosome, a microtubule organising centre, and to the spindle. At the centrosome it binds microtubules as part of the gamma-tubulin ring complex. The protein is required for microtubule formation and for progression of the cell cycle. Beyond mitotic functions, UniProt also notes a role in sperm morphological development during late-stage spermiogenesis, particularly the anchoring of the sperm head to the tail.
The TUBG1 gene is classed by HGNC in the tubulin gamma family, and earlier names include tubulin, gamma polypeptide and tubulin, gamma 1. A pseudogene of this gene is found on chromosome 7. Mouse and rat each carry an ortholog named Tubg1, which allows the protein to be studied in common model systems.
Gamma-tubulin is a core component of the gTuRC, which drives minus-end nucleation of alpha-beta tubulin heterodimers into microtubule protofilaments.
TUBG1 localises to the centrosome, and the gTuRC it forms is central to the centrosome duplication step.
The protein is required for microtubule formation and cell cycle progression, and is found at the spindle.
TUBG1 contributes to late-stage sperm development, particularly anchoring of the sperm head to the tail.
TUBG1 encodes gamma-tubulin, a key component of the gamma-tubulin ring complex (gTuRC). The complex mediates minus-end nucleation of microtubules, a critical step in centrosome duplication and spindle formation. The protein is required for microtubule formation and cell cycle progression.
The approved HGNC name is tubulin gamma 1, and UniProt calls the protein tubulin gamma-1 chain. Aliases include TUBG and TUBGCP1. Earlier names were tubulin, gamma polypeptide and tubulin, gamma 1. Take care to distinguish it from TUBGCP4 and other gTuRC subunits.
Mouse and rat both have an ortholog named Tubg1. The human gene also has a pseudogene on chromosome 7. Researchers working in rodent models should check the datasheet of any product for its validated reactivity.
Other components of the gamma-tubulin ring complex and microtubule-nucleation machinery with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P23258; product specifications from Assay Genie datasheets.