GIP
GIP (gastric inhibitory polypeptide) is a secreted incretin hormone of the glucagon family. It is a potent stimulator of insulin secretion from pancreatic beta-cells and a relatively poor inhibitor of gastric acid secretion. Browse Assay Genie's current range of GIP research reagents below, or read on for the biology behind the target.
GIP is an incretin hormone, a class of gut-derived signal released after food ingestion and nutrient absorption. Its principal role is in maintaining glucose homeostasis: it is a potent stimulator of insulin secretion from pancreatic beta-cells. It acts through a G protein-coupled receptor, GIPR, whose activation stimulates adenylyl cyclase and other signal transduction pathways to drive insulin release. By contrast, GIP is a relatively poor inhibitor of gastric acid secretion, which is reflected in its original name.
The human GIP gene encodes a secreted precursor protein of 153 amino acids. UniProt places it in the glucagon family, and the NCBI Gene summary describes it as a member of the glucagon superfamily. HGNC classifies the gene within the neuropeptides group. Orthologous genes, named Gip, are present in mouse and rat, so the hormone can be studied in common rodent models of glucose regulation.
The official name, gastric inhibitory polypeptide, comes from the early observation that the peptide inhibits gastric acid secretion. The sourced annotation now emphasises its stronger effect on insulin secretion. Researchers working on incretin biology, beta-cell signalling and nutrient-stimulated hormone release often study GIP alongside its receptor, so the GIP protein and its measurement are of broad interest in metabolic research.
GIP helps maintain glucose homeostasis by stimulating insulin secretion after food ingestion and nutrient absorption.
GIP acts on beta-cells through a G protein-coupled receptor that activates adenylyl cyclase and other signal transduction pathways.
As an incretin of the glucagon superfamily, GIP is a reference point for studying gut hormone responses to nutrients.
GIP is a relatively poor inhibitor of gastric acid secretion, making it useful for comparing gut peptide effects.
GIP is an incretin hormone that potently stimulates insulin secretion from pancreatic beta-cells after food ingestion and nutrient absorption, helping maintain glucose homeostasis. It signals through a G protein-coupled receptor that activates adenylyl cyclase. It is a relatively poor inhibitor of gastric acid secretion.
The approved name is gastric inhibitory polypeptide, and no alternative symbols are listed by HGNC. GIP belongs to the glucagon family according to UniProt, and to the glucagon superfamily according to the NCBI Gene summary. HGNC places the gene in the neuropeptides group.
Yes. Mouse and rat both have an ortholog named Gip, so the hormone can be studied in rodent models as well as in human samples. Check the datasheet of any product for its validated reactivity before choosing a reagent for a given species.
The GIP receptor, which mediates GIP signalling through adenylyl cyclase activation, has its own page at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P09681; product specifications from Assay Genie datasheets.