H-FABP
H-FABP (fatty acid binding protein 3, encoded by FABP3) is a small cytoplasmic member of the fatty acid-binding protein family, thought to carry long-chain fatty acids inside the cell. It is also known as O-FABP, MDGI and FABP11. Browse Assay Genie's current range of H-FABP research reagents below, or read on for the biology behind the target.
H-FABP belongs to the intracellular fatty acid-binding proteins (FABPs), a multigene family within the calycin superfamily. FABPs are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters, and to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also contribute to the modulation of cell growth and proliferation.
The family is divided into at least three distinct types, namely hepatic, intestinal and cardiac. H-FABP is the cardiac-type member. Like other FABPs it forms a protein of 14-15 kDa and is found in the cytoplasm. The human FABP3 gene contains four exons, and alternative splicing results in multiple transcript variants. Mouse and rat both carry an orthologous Fabp3 gene.
The alternative names reflect the protein's history. FABP3 has previously been listed as fatty acid binding protein 11 and as fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor), which is the origin of the alias MDGI. In line with that name, the gene's function is described as arresting the growth of mammary epithelial cells, and it is regarded as a candidate tumour suppressor gene for human breast cancer.
H-FABP is thought to take part in the uptake, intracellular metabolism and transport of long-chain fatty acids and their acyl-CoA esters.
FABPs may modulate cell growth and proliferation, and FABP3 is described as arresting the growth of mammary epithelial cells.
FABP3 is a candidate tumour suppressor gene for human breast cancer, making it a subject of study in tumour biology.
H-FABP is the cardiac-type member of a family that also includes hepatic and intestinal types, allowing comparison of FABP functions.
H-FABP is thought to participate in the uptake, intracellular metabolism and transport of long-chain fatty acids and their acyl-CoA esters. It may also modulate cell growth and proliferation, and the FABP3 gene is described as arresting growth of mammary epithelial cells.
The gene symbol is FABP3, and aliases include O-FABP, MDGI and FABP11. Earlier names were fatty acid binding protein 11 and fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor). UniProt lists it as fatty acid-binding protein, heart. Alternative splicing gives multiple transcript variants.
Mouse and rat each have an orthologous Fabp3 gene, so H-FABP can be studied in common model species; check the datasheet of any product for its validated reactivity. FABP3 is also considered a candidate tumour suppressor gene for human breast cancer.
Other fatty acid-binding proteins from the same calycin-superfamily family, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P05413; product specifications from Assay Genie datasheets.