HSP90B1
HSP90B1 (heat shock protein 90 beta family member 1), also known as endoplasmin, GP96, GRP94 and TRA1, is an ATP-dependent molecular chaperone of the endoplasmic reticulum. It helps fold and traffic client proteins, including components of Wnt and Toll-like receptor signalling. Browse Assay Genie's current range of HSP90B1 research reagents below, or read on for the biology behind the target.
HSP90B1 is an ATP-dependent chaperone involved in the processing of proteins in the endoplasmic reticulum, where it regulates their transport. It acts on specific clients. Together with MESD, it modulates the Wnt pathway by promoting the folding of LRP6, a coreceptor of the canonical Wnt pathway. When associated with CNPY3, it is required for the proper folding of Toll-like receptors, and it promotes the folding and trafficking of TLR4 to the cell surface.
The source annotation also suggests that HSP90B1 may take part in unfolding cytosolic leaderless cargos, which lack a secretion signal sequence, such as interleukin 1 (IL-1). This would help their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) before secretion, a process mediated by the cargo receptor TMED10.
The HSP90B1 gene encodes a member of the heat shock protein 90 family, a group of ATP-metabolising molecular chaperones that stabilise and fold other proteins. The protein is localised to the endoplasmic reticulum lumen, the sarcoplasmic reticulum lumen and melanosomes. Expression of the protein is associated with a variety of pathogenic states, including tumour formation. A microRNA gene lies within the 5' exon of the HSP90B1 gene, and pseudogenes exist on chromosomes 1 and 15. Earlier names include tumour rejection antigen (gp96) 1 and heat shock protein 90kDa beta (Grp94), member 1. The mouse and rat orthologues are both called Hsp90b1.
HSP90B1 is an ATP-dependent chaperone that processes proteins in the endoplasmic reticulum and regulates their transport.
With MESD, HSP90B1 promotes folding of LRP6, a coreceptor of the canonical Wnt pathway, making it relevant to Wnt modulation.
HSP90B1 is required, with CNPY3, for Toll-like receptor folding and promotes TLR4 folding and trafficking to the cell surface.
Expression of HSP90B1 is associated with pathogenic states including tumour formation, so it is studied in cancer research.
HSP90B1 is an ATP-dependent chaperone in the endoplasmic reticulum that processes proteins and regulates their transport. It promotes folding of LRP6 with MESD, supports Toll-like receptor folding with CNPY3, and promotes TLR4 trafficking to the cell surface.
HSP90B1 is also called endoplasmin, GP96, GRP94 and TRA1. Earlier HGNC names were tumour rejection antigen (gp96) 1 and heat shock protein 90kDa beta (Grp94), member 1. These names refer to the same gene and protein, so check which is used when comparing literature.
Mouse and rat both have an orthologue named Hsp90b1. NCBI Gene notes that HSP90B1 expression is associated with a variety of pathogenic states, including tumour formation. Check the datasheet of any product for its validated reactivity.
Other heat shock proteins and chaperones, including HSP90 and HSP70 family members, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P14625; product specifications from Assay Genie datasheets.