IL-25
IL-25 (interleukin 25, also known as IL-17E) is a secreted cytokine of the IL-17 family that promotes and augments T-helper type 2 responses. It is produced by cells including eosinophils, Th2 cells and epithelial cells. Browse Assay Genie's current range of IL-25 research reagents below, or read on for the biology behind the target.
IL-25 is a cytokine produced by various cells, including eosinophils, T-helper type 2 (Th2) cells and epithelial cells. It plays a role in the internal safety of adaptive immune responses by regulating cytokine production, and it promotes and augments Th2 responses both locally and systemically. IL-25 signals through a receptor composed of IL17RA and IL17RB. Receptor engagement stimulates the JAK2-STAT5A pathway and promotes secretion of type-2 associated cytokines, including IL-4, IL-9 and IL-13.
IL-25 also induces the release of IL-8 and IL-6 from eosinophils through combined activation of the MAPK and NF-kappa-B pathways. In turn, the IL-4, IL-5 and IL-13 produced in response inhibit the differentiation of T-helper 17 (Th17) cells. NCBI Gene notes that IL-25 shares sequence similarity with IL-17, can induce NF-kappaB activation and stimulates IL-8 production. Studies of a similar gene in mice suggest it may be a pro-inflammatory cytokine favouring the Th2-type response.
The IL25 gene encodes a secreted protein, and alternative splicing results in multiple transcript variants. HGNC classes it within the interleukins and the IL-17 family, and its previous name was interleukin 17E, hence the aliases IL-17E and IL17E. Both IL-25 and IL-17B are ligands for the cytokine receptor IL17BR. The mouse ortholog is designated Il25.
IL-25 promotes Th2 responses and drives secretion of IL-4, IL-9 and IL-13, making it a focus for studies of type-2 cytokine regulation.
IL-25 is produced by eosinophils and induces IL-8 and IL-6 release from them through MAPK and NF-kappa-B activation.
IL-25 inhibits Th17 differentiation via IL-4, IL-5 and IL-13 production, relevant to research on the balance between T-helper subsets.
As an IL-17 family member signalling through IL17RA and IL17RB, IL-25 is used to study receptor usage, JAK2-STAT5A and NF-kappaB pathways.
IL-25 is a secreted cytokine that promotes and augments T-helper type 2 responses. It signals through an IL17RA and IL17RB receptor, activating the JAK2-STAT5A pathway and stimulating IL-4, IL-9 and IL-13 secretion. It also induces IL-8 and IL-6 release from eosinophils and inhibits Th17 differentiation.
Yes. IL-25 was previously named interleukin 17E, and IL-17E and IL17E remain recognised aliases. The name reflects its membership of the IL-17 family and its sequence similarity to IL-17. The gene symbol is IL25, and alternative splicing gives multiple transcript variants.
A mouse ortholog, Il25, exists, and studies of a similar gene in mice suggest a pro-inflammatory role favouring Th2-type responses. IL-25 acts through a receptor of IL17RA and IL17RB; IL17BR is also a receptor for IL-17B. Check the datasheet of any product for its validated reactivity.
Other IL-17 family members, type-2 associated interleukins and related cytokines with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9H293; product specifications from Assay Genie datasheets.