KIM-1
KIM-1, encoded by the HAVCR1 gene and also known as TIM-1, TIM1, HAVCR-1, TIMD1 or CD365, is a cell-membrane receptor of the immunoglobulin superfamily. It acts as a receptor for human hepatitis A virus and for TIMD4, and as an entry factor for several other viruses. Browse Assay Genie's current range of KIM-1 research reagents below, or read on for the biology behind the target.
KIM-1 (hepatitis A virus cellular receptor 1) is a membrane receptor for both human hepatitis A virus (HHAV) and TIMD4. It also plays a positive role in Chikungunya virus cell entry. The NCBI Gene summary describes it as a receptor for multiple other viruses, including Ebola virus, Marburg virus, Dengue virus and Zika virus, and as a possible entry factor for SARS-CoV-2 and other coronaviruses. This makes the KIM-1 protein a frequent subject in studies of viral entry.
The protein belongs to the immunoglobulin superfamily and the TIM family. In HGNC, the KIM-1 gene (symbol HAVCR1) is placed in the groups of CD molecules and V-set domain containing proteins. UniProt records its location as the cell membrane, with additional annotation at the phagocytic cup, a cell projection, and in phagosomes within cytoplasmic vesicles. Mouse and rat both carry a Havcr1 ortholog.
Beyond virus binding, the encoded protein may be involved in moderating asthma and allergic diseases. According to the NCBI summary, the reference genome represents an allele that retains a MTTVP amino acid segment, which confers protection against atopy in HHAV seropositive individuals. The gene is known under several names, including HAVCR, HAVCR-1, TIM-1, TIM1, TIMD1, CD365 and KIM1, so it helps to search under all of them when reviewing the literature.
KIM-1 is a receptor for hepatitis A virus and is implicated in entry of Ebola, Marburg, Dengue, Zika and Chikungunya viruses.
The protein is described as a possible entry factor for SARS-CoV-2 and other coronaviruses, making it relevant to host-factor investigations.
The encoded protein may moderate asthma and allergic diseases, and a MTTVP segment is linked to protection against atopy in HHAV seropositive individuals.
As a TIM family member that binds TIMD4, KIM-1 is a useful target for studying receptor-ligand interactions within this immunoglobulin superfamily group.
KIM-1 is a membrane receptor for human hepatitis A virus and for TIMD4. It plays a positive role in Chikungunya virus cell entry and is a receptor for other viruses, including Ebola, Marburg, Dengue and Zika viruses. It may also be involved in moderating asthma and allergic disease.
The official gene symbol is HAVCR1, and the protein is named hepatitis A virus cellular receptor 1. Aliases include HAVCR-1, HAVCR, TIM-1, TIM1, TIMD1, CD365 and KIM1. Searching under these names helps when you compare literature, an anti-KIM-1 antibody or a KIM-1 ELISA kit.
Yes. Both mouse and rat have an ortholog named Havcr1. Because the human protein belongs to the TIM family within the immunoglobulin superfamily, rodent models are commonly considered, but check the datasheet of any product for its validated reactivity.
Other TIM family members, viral entry receptors and ligand partners related to KIM-1 with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q96D42; product specifications from Assay Genie datasheets.