MCP-2
MCP-2 (monocyte chemotactic protein 2), encoded by the CCL8 gene, is a secreted CC chemokine that attracts monocytes, lymphocytes, basophils and eosinophils. It is also known as C-C motif chemokine 8, HC14 and SCYA8. Browse Assay Genie's current range of MCP-2 research reagents below, or read on for the biology behind the target.
MCP-2 is a chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. By recruiting leukocytes to sites of inflammation, it may contribute to inflammatory host responses, to tumour-associated leukocyte infiltration and to the antiviral state against HIV infection. UniProt also notes that it may play a role in neoplasia, and that the protein can bind heparin.
A processed form, MCP-2(6-76), does not show monocyte chemotactic activity. Instead it inhibits the chemotactic effect of other chemokines, most predominantly CCL7 and also CCL2, CCL5 and CCL8. Processing of the protein can therefore change its activity from agonist to inhibitor of chemokine signalling.
MCP-2 belongs to the intercrine beta (CC chemokine) family. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies according to the arrangement of N-terminal cysteine residues in the mature peptide, and the CC subfamily is characterised by two adjacent cysteines. The CCL8 gene is one of several chemokine genes clustered on the q-arm of chromosome 17, and NCBI describes it as an antimicrobial gene. The mouse ortholog is Ccl8. Earlier names include small inducible cytokine subfamily A (Cys-Cys), member 8 (monocyte chemotactic protein 2) and chemokine (C-C motif) ligand 8.
MCP-2 recruits monocytes, lymphocytes, basophils and eosinophils, making it relevant to studies of leukocyte trafficking in inflammatory host responses.
UniProt and NCBI link this chemokine to neoplasia and to tumour-associated leukocyte infiltration through its recruitment of leukocytes.
By recruiting leukocytes, MCP-2 may contribute to the antiviral state against HIV infection, as described in the NCBI Gene summary.
The processed form MCP-2(6-76) inhibits chemotaxis driven by CCL7, CCL2 and CCL5, offering a model for antagonism within the chemokine network.
MCP-2 is a secreted chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. It may play a role in neoplasia and inflammatory host responses, and it can bind heparin. A processed form, MCP-2(6-76), lacks monocyte chemotactic activity and inhibits the effects of other chemokines.
The HGNC symbol is CCL8, for C-C motif chemokine ligand 8. Aliases include MCP-2, HC14 and SCYA8. Previous names include small inducible cytokine subfamily A (Cys-Cys), member 8 (monocyte chemotactic protein 2) and chemokine (C-C motif) ligand 8.
Mouse has an ortholog named Ccl8. In humans, the CCL8 gene sits in a cluster of chemokine genes on the q-arm of chromosome 17. Check the datasheet of any product for its validated reactivity before using it with a particular species.
Other CC chemokine ligands involved in leukocyte recruitment and inflammatory signalling.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P80075; product specifications from Assay Genie datasheets.