Nectin-4
Nectin-4 (nectin cell adhesion molecule 4, encoded by NECTIN4) is a single-pass type I membrane protein of the nectin family that mediates cell adhesion. It is also known as PRR4, LNIR and PVRL4, and acts as a receptor for measles virus. Browse Assay Genie's current range of Nectin-4 research reagents below, or read on for the biology behind the target.
Nectin-4 is a member of the nectin family and is involved in cell adhesion through trans-homophilic and trans-heterophilic interactions. It is a single-pass type I membrane protein, and UniProt places it at the cell membrane and at adherens junctions. In the context of microbial infection, Nectin-4 acts as a receptor for measles virus.
The Nectin-4 protein contains one Ig-like V-type domain and two Ig-like C2-type domains, consistent with its HGNC classification in the V-set domain containing, C2-set domain containing, and nectins and nectin-like molecules gene groups. A soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17 (TACE), and this secreted form has been found in both breast tumour cell lines and breast tumour patients. Alternatively spliced transcript variants of the Nectin-4 gene have been reported, although the full-length nature of the variant has not been determined.
The gene was previously named poliovirus receptor-related 4 (PVRL4) and is now designated NECTIN4 by HGNC. Mutations in this gene cause ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Other nectin family members, including Nectin-1, Nectin-2 and Nectin-3, share the adhesion function of this group of immunoglobulin-like proteins. The mouse ortholog is designated Nectin4.
Nectin-4 mediates cell adhesion through trans-homophilic and trans-heterophilic interactions and localises to adherens junctions, making it relevant to studies of junction formation.
Nectin-4 acts as a receptor for measles virus, so it is studied in work on viral receptor usage and infection.
A soluble form of Nectin-4 is found in breast tumour cell lines and in breast tumour patients, linking it to tumour biology studies.
Mutations in NECTIN4 cause ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder, which makes the gene relevant to developmental genetics.
Nectin-4 is a nectin family cell adhesion molecule that acts through trans-homophilic and trans-heterophilic interactions. It is a single-pass type I membrane protein found at the cell membrane and adherens junctions, and it also serves as a receptor for measles virus.
Nectin-4 is also called PRR4, LNIR and PVRL4, and was formerly named poliovirus receptor-related 4. A soluble form is released when ADAM17 (TACE) cleaves the membrane protein at the cell surface. Alternatively spliced transcript variants have also been described.
Mutations in NECTIN4 cause ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. The secreted form is found in breast tumour cell lines and patients. A mouse ortholog, Nectin4, exists; check the datasheet of any product for its validated reactivity.
Other nectin family adhesion molecules with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q96NY8; product specifications from Assay Genie datasheets.