AMBP
AMBP (alpha-1-microglobulin/bikunin precursor) is a complex glycoprotein secreted in plasma that is processed into two functional proteins, alpha-1-microglobulin and bikunin. It is also known as UTI, HCP, EDC1, HI30, IATIL, ITILC, ITI and ITIL. Browse Assay Genie's current range of AMBP research reagents below, or read on for the biology behind the target.
AMBP encodes a single precursor that is proteolytically processed into distinct functioning proteins. One is alpha-1-microglobulin, a member of the lipocalin superfamily of transport proteins, which may play a role in the regulation of inflammatory processes. The other is bikunin, a urinary trypsin inhibitor of the Kunitz-type protease inhibitor superfamily that has an important role in many physiological and pathological processes.
As a Kunitz-type serine protease inhibitor, the protein shows high catalytic efficiency towards coagulation factor Xa (F10) and may act as an anticoagulant by inhibiting prothrombin activation. It also inhibits trypsin and the mast cell proteases chymase (CMA1) and tryptase. The N-terminal section belongs to the calycin superfamily and the lipocalin family.
The AMBP gene sits on chromosome 9 within a cluster of lipocalin genes, and the product is secreted into plasma as a complex glycoprotein. UniProt records a wide set of subcellular locations beyond the secreted pool, including the endoplasmic reticulum, cytosol, cell membrane, nuclear membrane, inner mitochondrial membrane and extracellular matrix. HGNC places AMBP in the lipocalin and oxidoreductase gene groups. Mouse and rat both carry an Ambp ortholog, which supports comparative work on the AMBP protein in rodent models.
Bikunin is a Kunitz-type inhibitor of trypsin, chymase and tryptase, making AMBP relevant to work on serine protease regulation.
AMBP inhibits factor Xa with high catalytic efficiency and may act as an anticoagulant by blocking prothrombin activation.
The alpha-1-microglobulin portion belongs to the lipocalin family and may play a role in regulating inflammatory processes.
AMBP lies in a chromosome 9 lipocalin gene cluster, offering a context for comparing lipocalin transport proteins.
AMBP is a precursor that yields alpha-1-microglobulin, a lipocalin that may regulate inflammatory processes, and bikunin, a Kunitz-type serine protease inhibitor. It inhibits factor Xa, trypsin, chymase and tryptase, and may act as an anticoagulant by inhibiting prothrombin activation.
The HGNC name is alpha-1-microglobulin/bikunin precursor, and UniProt lists it as Protein AMBP. Aliases include UTI, HCP, EDC1, HI30, IATIL, ITILC, ITI and ITIL. Bikunin is described as a urinary trypsin inhibitor, which explains the UTI alias.
Yes. Orthologs named Ambp are listed for both mouse and rat. This allows AMBP biology to be studied in rodent systems, but check the datasheet of any product for its validated reactivity.
Other lipocalins, serine proteases, coagulation factors and protease inhibitor targets related to AMBP biology.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P02760; product specifications from Assay Genie datasheets.