FLT3LG
FLT3LG (fms related receptor tyrosine kinase 3 ligand) is a receptor ligand that stimulates the proliferation of early haematopoietic cells by activating FLT3. It is required for the development of B cells and dendritic cells. Browse Assay Genie's current range of FLT3LG research reagents below, or read on for the biology behind the target.
FLT3LG is the ligand for the receptor FLT3. By activating FLT3, it stimulates the proliferation of early haematopoietic cells. It also synergises well with a number of other colony stimulating factors and interleukins, which places it among the signals that shape blood cell production. It is required for the development of B cells and of dendritic cells (DCs).
The FLT3LG protein is annotated in UniProt as both a cell membrane and a secreted protein. Its human gene symbol is FLT3LG, and HGNC places it in the receptor ligands gene group. The mouse ortholog is Flt3lg, which is useful for researchers who work with murine models of haematopoiesis and immunity.
DCs provide the key link between innate and adaptive immunity. They recognise pathogens and prime pathogen-specific immune responses. According to the NCBI Gene summary, the FLT3LG gene controls the development of DCs. It is particularly important for plasmacytoid DCs and for CD8-positive classical DCs, together with their CD103 (ITGAE)-positive tissue counterparts. The protein was previously named fms-related tyrosine kinase 3 ligand, and that name is still used in the literature and in UniProt. Researchers studying FLT3 signalling, early haematopoietic expansion or DC lineage development often study FLT3LG alongside its receptor.
FLT3LG stimulates the proliferation of early haematopoietic cells through FLT3 and synergises with several colony stimulating factors and interleukins.
FLT3LG controls dendritic cell development, with particular importance for plasmacytoid DCs and CD8-positive classical DCs.
DCs link innate and adaptive immunity by recognising pathogens and priming specific responses, and FLT3LG governs their development.
FLT3LG is required for the development of B cells, making it relevant to studies of lymphoid lineage differentiation.
FLT3LG activates the receptor FLT3 and so stimulates the proliferation of early haematopoietic cells. It synergises well with a number of other colony stimulating factors and interleukins. It is also required for the development of B cells and dendritic cells.
UniProt names the protein fms-related tyrosine kinase 3 ligand, and HGNC lists the full name as fms related receptor tyrosine kinase 3 ligand. No other aliases are recorded. UniProt annotates it as present at the cell membrane and as a secreted protein.
The NCBI Gene summary states that FLT3LG controls dendritic cell development. It is particularly important for plasmacytoid DCs and CD8-positive classical DCs, plus their CD103 (ITGAE)-positive tissue counterparts. The mouse ortholog is Flt3lg; check the datasheet of any product for its validated reactivity.
The FLT3 receptor that FLT3LG activates, with related reagents for haematopoiesis and dendritic cell research.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P49771; product specifications from Assay Genie datasheets.