GAST
GAST encodes gastrin, a secreted peptide hormone of the gastrin/cholecystokinin family that drives gastric acid secretion and pancreatic enzyme release. The gene is also listed under the alias GAS and sits within the HGNC neuropeptides gene group. Browse Assay Genie's current range of GAST research reagents below, or read on for the biology behind the target.
Gastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa. Acid production in turn results in inhibition of further gastrin formation, a negative feedback arrangement. Gastrin also stimulates the pancreas to secrete its digestive enzymes, promotes smooth muscle contraction, and increases blood circulation and water secretion in the stomach and intestine.
The GAST gene encodes a secreted precursor that belongs to the gastrin/cholecystokinin family. Gastrin has two biologically active peptide forms, G34 and G17. Beyond its secretory roles, the hormone acts as a mitogenic factor for gastrointestinal epithelial cells, linking it to the growth and maintenance of the gut lining.
HGNC classifies the gene as gastrin within the neuropeptides group, and GAS is a recorded alias. Mouse and rat each carry an ortholog named Gast, so the hormone can be studied in common rodent models. Researchers working on digestive physiology, epithelial proliferation and peptide hormone signalling investigate the gastrin protein and the GAST gene in these contexts.
Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid, making it a central hormone for studying acid secretion and its feedback control.
Gastrin stimulates the pancreas to secrete digestive enzymes, so it is relevant to research on digestive coordination between stomach and pancreas.
Gastrin acts as a mitogenic factor for gastrointestinal epithelial cells, which makes it a subject in studies of mucosal proliferation.
As a gastrin/cholecystokinin family member with active G34 and G17 forms, gastrin is a useful model for peptide processing and neuropeptide signalling.
Gastrin stimulates the stomach mucosa to secrete hydrochloric acid and the pancreas to secrete digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine. It acts as a mitogenic factor for gastrointestinal epithelial cells.
GAST is the approved HGNC symbol for gastrin, and GAS is a recorded alias. The hormone has two biologically active peptide forms, G34 and G17. Both derive from the same gene product, which is secreted and belongs to the gastrin/cholecystokinin family.
Yes. Both mouse and rat have an ortholog named Gast, which allows the hormone to be studied in rodent models. Check the datasheet of any product for its validated reactivity before choosing a reagent for a particular species.
Other gastrointestinal hormones, neuropeptides and gastrin/cholecystokinin family members with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P01350; product specifications from Assay Genie datasheets.