Lipopolysaccharide Binding Protein
Lipopolysaccharide Binding Protein (LBP, also known as BPIFD2) is a secreted protein of the innate immune system that binds the lipid A moiety of bacterial lipopolysaccharide. It presents LPS to CD14 and helps drive the acute-phase response to Gram-negative infection. Browse Assay Genie's current range of Lipopolysaccharide Binding Protein research reagents below, or read on for the biology behind the target.
Lipopolysaccharide Binding Protein (LBP) plays a role in the innate immune response. It binds the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid found in the outer membrane of all Gram-negative bacteria. LBP acts as an affinity enhancer for CD14, facilitating the association of CD14 with LPS, and it promotes the release of cytokines in response to bacterial LPS. Together with bactericidal permeability-increasing protein (BPI), it binds LPS and interacts with the CD14 receptor, probably regulating LPS-dependent monocyte responses.
The LBP gene encodes a protein that is involved in the acute-phase immunologic response to Gram-negative bacterial infections. UniProt records its location as secreted, and also as a cytoplasmic granule membrane protein. Studies in mice, where the ortholog is Lbp, suggest that the protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. A rat ortholog, also named Lbp, has been described.
LBP belongs to the BPI/LBP/Plunc superfamily and the BPI/LBP family, and HGNC places it in the BPI fold containing gene group, where BPIFD2 is a previous symbol. It is part of a family of structurally and functionally related proteins that includes BPI, plasma cholesteryl ester transfer protein (CETP) and phospholipid transfer protein (PLTP). Researchers studying LPS recognition, monocyte activation and cytokine release often work with the LBP protein, and with LBP antibody or LBP ELISA kit approaches, to follow this pathway.
LBP takes part in the innate immune response by binding bacterial lipopolysaccharide and passing it to CD14.
LBP is involved in the acute-phase response to Gram-negative infection, and mouse studies indicate it is needed for the rapid response to LPS.
With BPI, LBP interacts with CD14 and probably regulates LPS-dependent monocyte responses.
LBP promotes cytokine release in response to bacterial lipopolysaccharide, making it relevant to inflammatory signalling studies.
LBP binds the lipid A moiety of bacterial lipopolysaccharide and acts as an affinity enhancer for CD14, helping CD14 associate with LPS. It promotes cytokine release in response to LPS and is involved in the acute-phase response to Gram-negative bacterial infection.
The HGNC-approved name is lipopolysaccharide binding protein, and UniProt uses lipopolysaccharide-binding protein. BPIFD2 is a previous symbol for the gene, reflecting its place in the BPI fold containing gene group. The gene symbol is LBP.
Mouse and rat both have an ortholog named Lbp, and mouse studies have informed understanding of its role in the acute-phase response. LBP belongs to the BPI/LBP/Plunc superfamily, alongside BPI, CETP and PLTP. Check the datasheet of any product for its validated reactivity.
Receptor partners and BPI fold family members relevant to LPS recognition and innate immune signalling.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P18428; product specifications from Assay Genie datasheets.