ICAM-1
ICAM-1 (intercellular adhesion molecule 1, also known as CD54 and BB2) is a cell surface glycoprotein of the immunoglobulin superfamily. It is typically expressed on endothelial cells and cells of the immune system, where it binds leukocyte integrins. Browse Assay Genie's current range of ICAM-1 research reagents below, or read on for the biology behind the target.
ICAM-1 is a cell surface glycoprotein that acts as a ligand for integrins. According to the NCBI Gene summary, it binds integrins of type CD11a/CD18 and CD11b/CD18, which links cells expressing ICAM-1 to leukocytes carrying these integrin heterodimers. It is typically expressed on endothelial cells and cells of the immune system, and it is a membrane-bound protein found at the cell membrane. It is also exploited by rhinovirus as a receptor, making it a point of contact between host cells and a common respiratory pathogen.
The ICAM-1 gene (ICAM1) encodes a protein that belongs to the immunoglobulin superfamily and the ICAM family. HGNC places it among the CD molecules, receptor ligands, immunoglobulin-like domain-containing proteins and the Ig-like cell adhesion molecule family. The protein is widely referred to by its CD designation, CD54, and carries the further alias BB2. Mouse and rat each have an orthologous Icam1 gene, so ICAM-1 can be studied in common rodent models. Related family members such as ICAM2, ICAM3, ICAM4 and ICAM5 share the ICAM family classification.
ICAM-1 also features in host-virus interactions beyond rhinovirus. UniProt records that, on infection with Kaposi's sarcoma-associated herpesvirus (HHV-8), ICAM-1 is degraded by the viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cells. This illustrates how the protein's presence at the cell surface influences immune recognition, and why it is a frequent subject in immunology and virology research on the ICAM-1 protein.
ICAM-1 binds the integrins CD11a/CD18 and CD11b/CD18, making it a central ligand for studying adhesion between endothelial cells and immune cells.
ICAM-1 is typically expressed on endothelial cells, so it is widely examined as a surface marker of the endothelium.
Rhinovirus exploits ICAM-1 as a receptor, so the protein is relevant to studies of viral entry and host-cell tropism.
In HHV-8 infection, ICAM-1 is degraded by the viral E3 ligase MIR2, presumably limiting lysis of infected cells by T-lymphocytes and NK cells.
ICAM-1 is a cell surface glycoprotein typically expressed on endothelial cells and cells of the immune system. It binds the integrins CD11a/CD18 and CD11b/CD18, and rhinovirus exploits it as a receptor. It is located at the cell membrane.
The HGNC gene symbol is ICAM1, and the approved name is intercellular adhesion molecule 1. Recorded aliases are CD54 and BB2. The protein is classed among the CD molecules and belongs to the immunoglobulin superfamily, ICAM family.
Yes. Mouse and rat each have an orthologous gene named Icam1, so ICAM-1 can be investigated in rodent models. Check the datasheet of any product for its validated reactivity.
Other ICAM family members from the immunoglobulin superfamily, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P05362; product specifications from Assay Genie datasheets.