Club Cell Protein
Club Cell Protein (SCGB1A1), also known as uteroglobin, CC10, CCSP, CC16 and UGB, is a small secreted member of the secretoglobin family. It binds lipids and hydrophobic ligands and is a potent inhibitor of phospholipase A2. Browse Assay Genie's current range of Club Cell Protein research reagents below, or read on for the biology behind the target.
Club Cell Protein is a small secreted protein that belongs to the secretoglobin family. UniProt annotates it as a binder of phosphatidylcholine, phosphatidylinositol and polychlorinated biphenyls (PCBs), with weak binding to progesterone, and as a potent inhibitor of phospholipase A2. The NCBI Gene summary adds that the protein has been implicated in numerous functions, including anti-inflammation and the sequestering of hydrophobic ligands.
The SCGB1A1 gene (secretoglobin family 1A member 1) encodes a precursor that is secreted from the cell. The human gene sits in the HGNC secretoglobin gene group, and orthologous genes named Scgb1a1 are annotated in both mouse and rat. This makes rodent models a common route for studying the protein's biology, although species-specific behaviour should always be confirmed.
The protein has several names. Its previous name, uteroglobin, is still used as the UniProt protein name, and the aliases CC10, CCSP, CC16 and UGB appear throughout the literature. Researchers searching for a Club Cell Protein antibody, CC16 ELISA kit or recombinant CC10 protein will find these names used interchangeably. Defects in the gene are associated with susceptibility to asthma, which has made the protein a subject of interest in airway inflammation research. Related secretoglobin family members include SCGB1D2, SCGB2A2 and SCGB3A2.
The protein has been implicated in anti-inflammatory functions, making it relevant to studies of inflammatory processes.
Defects in the gene are associated with susceptibility to asthma, so it is a candidate for genetic and mechanistic asthma research.
It is a potent inhibitor of phospholipase A2, which is useful for studying regulation of lipid-mediator pathways.
It binds phosphatidylcholine, phosphatidylinositol, PCBs and weakly progesterone, and is implicated in sequestering hydrophobic ligands.
Club Cell Protein is a small secreted protein that binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls and, weakly, progesterone. It is a potent inhibitor of phospholipase A2 and has been implicated in anti-inflammation and the sequestering of hydrophobic ligands.
The protein was first named uteroglobin, which remains its UniProt protein name. The aliases CC10, CCSP, CC16 and UGB are also used, and the approved HGNC gene symbol is SCGB1A1, reflecting its place in the secretoglobin family. All refer to the same gene and protein.
Defects in the gene are associated with susceptibility to asthma. Mouse and rat both carry an ortholog named Scgb1a1, so rodent studies are possible. Check the datasheet of any product for its validated reactivity.
Other secretoglobin family members with research products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P11684; product specifications from Assay Genie datasheets.