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B220 Monoclonal Antibody [mB220] (CPAB0355)

SKU:
CPAB0355
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Host Species:
Rat
Isotype:
IgM
Clone:
mB220
€660
Frequently bought together:

Description

system_update_alt Datasheet
Product Name:B220 Antibody
Product Sku:CPAB0355
Size:500μg
Host Species:Rat
Immunogen:Purified mouse LN B cells.
Clone:mB220.
Reactivity:Mouse
Applications:
Purification Method:Ion exchange column.
Isotype:IgM
Background:B220 (CD45R) is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. B220 (CD45R) is required for t-cell activation through the antigen receptor. The first ptpase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one.
Synonyms:LCA, PTPRC, LY5, B220, CD45R, T200, GP180, PROTEIN-TYROSINE PHOSPHATASE, RECEPTOR-TYPE C.
Storage Buffer:Lyophilized: store at 4C. After reconstitution, if not intended for use within a month, aliquot and store at -20C.

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