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CD40 Monoclonal Antibody [hCD40] (CPAB0324)

SKU:
CPAB0324
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
hCD40
€660
Frequently bought together:

Description

system_update_alt Datasheet
Product Name:CD40 Antibody
Product Sku:CPAB0324
Size:500μg
Host Species:Mouse
Immunogen:Activated Human B cells.
Clone:hCD40.
Reactivity:Human
Applications:
Purification Method: Protein A
Isotype:IgG1
Background:CD40 is part of the TNF-receptor superfamily. CD40 is a necessary mediator for vast range of immune and inflammatory responses together with T cell-dependent immunoglobulin class switching, memory B cell growth, and germinal center formation. The transcription factor AKNA regulates the expression of CD40 and its ligand, which is vital for homotypic cell interactions. Adaptor protein TNFR2 interacts with CD40 and serves as a mediator of the signal transduction. The interaction of CD40 and its ligand is crucial for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. CD40 is the receptor for TNFSF5/CD40L.
Synonyms:p50, Bp50, CDW40, MGC9013, TNFRSF5, CD40.
Storage Buffer:Lyophilized: store at 4°C. After reconstitution, if not intended for use within a month, aliquot and store at -20°C.

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