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PGP9.5 Monoclonal Antibody [P3D9AT] (CPAB0520)

SKU:
CPAB0520
Product type:
Antibody
Reactivity:
Other bodies
Host Species:
Mouse
Isotype:
IgG2a
Clone:
P3D9AT
Application:
WB
Application:
ELISA
Application:
IHC
€180

Description

Technical Manual

PGP9.5 Monoclonal Antibody [P3D9AT] (CPAB0520)

Product Name:PGP9.5 Antibody
Product Sku:CPAB0520
Size:5μg
Host Species:Mouse
Purification Method:PGP95 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Isotype:IgG2a
Background:UCHL1 (PGP9.5) belongs to a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to produce the ubiquitin monomer. Protein Gene Product (PGP9.5) is a neuron specific protein, structurally and immunologically distinct from neuron specific enolase. Human UCHL1 and UCHL3 have an extremely complicated knot structure for a protein, with five knot crossings. It is considered that the knot structure may increase a protein''s resistance to degradation in the proteasome. The protein, which has a molecular weight of 27 kDa was first defined by high resolution two dimetional PAGE. Standard immunohistochemical techniques have demonstrated the presence of PGP9.5 in neurons and nerve fibers at all levels of the central and peripheral nervous system, in many neurodcrine cells, in segments of the renal tubules, in spermatogonia and leydig cells of the testis, in ova and in some cells of both the pregnant and non pregnant corpus luteum. A point mutation (I93M) in UCHL1 is implicat
Immunogen:Anti-human PGP9.5 mAb is derived from hybridization of mouse SP2/O myeloma cells with spleen cells from BALB/c mice immunized with recombinant human PGP9.5 amino acids 1-223 purified from Ecoli.
Synonyms:Ubiquitin carboxyl-terminal hydrolase isozyme L1, UCH-L1, EC 3.4.19.12, Ubiquitin thioesterase L1, Neuron cytoplasmic protein 9.5, PGP 9.5, UCHL1, PGP9.5, PARK5.
Clone:P3D9AT.
Reactivity:Other bodies
Applications:Western Blot, ELISA, Immunohistochemistry
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.