null

NPHS1 Rabbit Polyclonal Antibody (CAB3048)

SKU:
CAB3048
Product Type:
Antibody
Reactivity:
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
  • Cell Biology Antibodies 8 Anti-NPHS1 Antibody CAB3048
  • Cell Biology Antibodies 8 Anti-NPHS1 Antibody CAB3048
  • Cell Biology Antibodies 8 Anti-NPHS1 Antibody CAB3048
  • Cell Biology Antibodies 8 Anti-NPHS1 Antibody CAB3048
€139 - €419
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:NPHS1 Rabbit Polyclonal Antibody
SKU:CAB3048
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1019-1241 of human NPHS1 (NP_004637.1).
Sequence:LGDS GLAD KGTQ LPIT TPGL HQPS GEPE DQLP TEPP SGPS GLPL LPVL FALG GLLL LSNA SCVG GVLW QRRL RRLA EGIS EKTE AGSE EDRV RNEY EESQ WTGE RDTQ SSTV STTE AEPY YRSL RDFS PQLP PTQE EVSY SRGF TGED EDMA FPGH LYDE VERT YPPS GAWG PLYD EVQM GPWD LHWP EDTY QDPR GIYD QVAG DLDT LEPD SLPF ELRG HLV
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:1000
Synonyms:CNF; NPHN; nephrin; NPHS1
Positive Sample:Mouse kidney,mouse brain,rat brain,Rat kidney
Conjugate:Unconjugated
Cellular Localization:Cell membrane, Single-pass type I membrane protein.
Calculated MW:135kDa
Observed MW:130kDa/180kDa

This gene encodes a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. The gene is primarily expressed in renal tissues, and the protein is a type-1 transmembrane protein found at the slit diaphragm of glomerular podocytes. The slit diaphragm is thought to function as an ultrafilter to exclude albumin and other plasma macromolecules in the formation of urine. Mutations in this gene result in Finnish-type congenital nephrosis 1, characterized by severe proteinuria and loss of the slit diaphragm and foot processes.

Purification Method:Affinity purification
Gene ID:4868
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from mouse kidney, using NPHS1 Rabbit pAb (CAB3048) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.

Related Products