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Anti-USP46 Antibody (CAB17863)

SKU:
CAB17863
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Developmental Biology
  • Developmental Biology Anti-USP46 Antibody CAB17863
  • Developmental Biology Anti-USP46 Antibody CAB17863
  • Developmental Biology Anti-USP46 Antibody CAB17863
€139 - €419
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Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-USP46 Antibody
Antibody SKU:CAB17863
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic Peptide of human USP46
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:1000 IHC 1:50 - 1:100 IF 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:mouse pancreas
Immunogen:A synthetic Peptide of human USP46
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:64854
Uniprot:P62068
Cellular Location:
Calculated MW:26kDa/41kDa/42kDa
Observed MW:42kDa
Synonyms:USP46
Background:
UniProt Protein Function:USP46: Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. May act by mediating the deubiquitination of GAD1/GAD67. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2. Belongs to the peptidase C19 family. USP12/USP46 subfamily. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Protease; EC 3.4.19.12; Ubiquitin-specific protease

Chromosomal Location of Human Ortholog: 4q12

Molecular Function:protein binding; ubiquitin-specific protease activity

Biological Process: ubiquitin-dependent protein catabolic process; protein deubiquitination; behavioral fear response; righting reflex; adult feeding behavior; behavioral response to ethanol; regulation of synaptic transmission, GABAergic

NCBI Summary:Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP46 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Jun 2009]
UniProt Code:P62068
NCBI GenInfo Identifier:49065850
NCBI Gene ID:64854
NCBI Accession:P62068.1
UniProt Secondary Accession:P62068,Q80V95, Q9H7U4, Q9H9T8, B7Z3Y7, B7Z675, B7Z7S3 G8ACC7,
UniProt Related Accession:P62068
Molecular Weight:366
NCBI Full Name:Ubiquitin carboxyl-terminal hydrolase 46
NCBI Synonym Full Names:ubiquitin specific peptidase 46
NCBI Official Symbol:USP46  
NCBI Protein Information:ubiquitin carboxyl-terminal hydrolase 46; ubiquitin thioesterase 46; deubiquitinating enzyme 46; ubiquitin thiolesterase 46; ubiquitin-specific-processing protease 46
UniProt Protein Name:Ubiquitin carboxyl-terminal hydrolase 46
UniProt Synonym Protein Names:Deubiquitinating enzyme 46; Ubiquitin thioesterase 46; Ubiquitin-specific-processing protease 46
Protein Family:Ubiquitin carboxyl-terminal hydrolase
UniProt Gene Name:USP46  
UniProt Entry Name:UBP46_HUMAN
Anti-USP46 Antibody (CAB17863)Western blot analysis of extracts of mouse pancreas, using USP46 antibody (CAB17863) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-USP46 Antibody (CAB17863)Immunofluorescence analysis of C6 cells using USP46 Polyclonal Antibody (CAB17863) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
Anti-USP46 Antibody (CAB17863)Immunofluorescence analysis of L-929 cells using USP46 Polyclonal Antibody (CAB17863) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.

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