ABCB1 Antibody (PACO18218)
- SKU:
- PACO18218
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | ABCB1 Antibody (PACO18218) |
| Antibody SKU: | PACO18218 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Synthetic peptide of human ABCB1 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO18218(ABCB1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO18218(ABCB1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. |
| Synonyms: | ATP-binding cassette, sub-family B (MDR/TAP), member 1 |
| UniProt Protein Function: | ABCB1: Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. Interacts with PSMB8. |
| UniProt Protein Details: | Protein type:Hydrolase; Cell adhesion; Transporter; Membrane protein, integral; Membrane protein, multi-pass; EC 3.6.3.44; Transporter, ABC family Chromosomal Location of Human Ortholog: 7q21.12 Cellular Component: cell surface; membrane; plasma membrane; integral to membrane Molecular Function:protein binding; ATPase activity, coupled to transmembrane movement of substances; transporter activity; xenobiotic-transporting ATPase activity; ATP binding Biological Process: response to drug; transport; multidrug transport; xenobiotic transport; G2/M transition of mitotic cell cycle; transmembrane transport Disease: Colchicine Resistance; Inflammatory Bowel Disease 13 |
| NCBI Summary: | The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P08183 |
| NCBI GenInfo Identifier: | 238054374 |
| NCBI Gene ID: | 5243 |
| NCBI Accession: | P08183.3 |
| UniProt Secondary Accession: | P08183,Q12755, Q14812, A8K294, B5AK60, |
| UniProt Related Accession: | P08183 |
| Molecular Weight: | 134,032 Da |
| NCBI Full Name: | Multidrug resistance protein 1 |
| NCBI Synonym Full Names: | ATP-binding cassette, sub-family B (MDR/TAP), member 1 |
| NCBI Official Symbol: | ABCB1 |
| NCBI Official Synonym Symbols: | CLCS; MDR1; P-GP; PGY1; ABC20; CD243; GP170 |
| NCBI Protein Information: | multidrug resistance protein 1; P-glycoprotein 1; colchicin sensitivity; doxorubicin resistance |
| UniProt Protein Name: | Multidrug resistance protein 1 |
| UniProt Synonym Protein Names: | ATP-binding cassette sub-family B member 1; P-glycoprotein 1; CD_antigen: CD243 |
| Protein Family: | ABC transporter B family |
| UniProt Gene Name: | ABCB1 |
| UniProt Entry Name: | MDR1_HUMAN |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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