The AGRP Polyclonal Antibody (CAB8044) is a specialized research tool designed for studying AGRP, a protein involved in regulating food intake and energy balance in the body. This antibody is produced in rabbits and shows high reactivity with human samples, making it an excellent choice for various research applications, including Western blot analysis.AGRP, or agouti-related protein, is known for its role in the central nervous system, where it acts as an antagonist of melanocortin receptors to promote appetite and lower energy expenditure. By understanding the function and regulation of AGRP, researchers can gain insights into metabolic disorders, obesity, and other conditions related to energy balance.
Furthermore, studying AGRP can provide valuable information for the development of potential therapies targeting appetite control and metabolic disorders. The AGRP Polyclonal Antibody (CAB8044) offers a reliable tool for investigating AGRP expression and function in different tissues and experimental models, making it a valuable asset for research in the fields of metabolism and endocrinology.
Product Name:
AGRP Rabbit Polyclonal Antibody
SKU:
CAB8044
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 21-132 of human AGRP (NP_001129.1).
This gene encodes an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation, and thus plays a role in weight homeostasis. Mutations in this gene have been associated with late on-set obesity.
Purification Method:
Affinity purification
Gene ID:
181
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse skeletal muscle, using AGRP Rabbit pAb (CAB8044) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
