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Anti-B3GALT4 Antibody (CAB15341)

SKU:
CAB15341
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction
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Description

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Antibody Name:Anti-B3GALT4 Antibody
Antibody SKU:CAB15341
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 80-270 of human B3GALT4 (NP_003773.1).
Application:WB
Recommended Dilution:WB 1:200 - 1:2000
Reactivity:Mouse
Positive Samples:Mouse heart
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 80-270 of human B3GALT4 (NP_003773.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:APEN LNQR NAIR ASWG GLRE ARGL RVQT LFLL GEPN AQHP VWGS QGSD LASE SAAQ GDIL QAAF QDSY RNLT LKTL SGLN WAEK HCPM ARYV LKTD DDVY VNVP ELVS ELVL RGGR WGQW ERST EPQR EAEQ EGGQ VLHS EEVP LLYL GRVH WRVN PSRT PGGR HRVS EEQW PHTW GPFP PYAS GTGY VLS
Gene ID:8705
Uniprot:O96024
Cellular Location:Golgi apparatus membrane, Single-pass type II membrane protein
Calculated MW:41kDa
Observed MW:42kDa
Synonyms:B3GALT4, BETA3GALT4, GALT2, GALT4, beta-1
Background:This gene is a member of the beta-1, 3-galactosyltransferase (beta3GalT) gene family. This family encodes type II membrane-bound glycoproteins with diverse enzymatic functions using different donor substrates (UDP-galactose and UDP-N-acetylglucosamine) and different acceptor sugars (N-acetylglucosamine, galactose, N-acetylgalactosamine). The beta3GalT genes are distantly related to the Drosophila Brainiac gene and have the protein coding sequence contained in a single exon. The beta3GalT proteins also contain conserved sequences not found in the beta4GalT or alpha3GalT proteins. The carbohydrate chains synthesized by these enzymes are designated as type 1, whereas beta4GalT enzymes synthesize type 2 carbohydrate chains. The ratio of type 1:type 2 chains changes during embryogenesis. By sequence similarity, the beta3GalT genes fall into at least two groups: beta3GalT4 and 4 other beta3GalT genes (beta3GalT1-3, beta3GalT5). This gene is oriented telomere to centromere in close proximity to the ribosomal protein S18 gene. The functionality of the encoded protein is limited to ganglioseries glycolipid biosynthesis.
UniProt Protein Function:B3GALT4: Involved in GM1/GD1B/GA1 ganglioside biosynthesis. Belongs to the glycosyltransferase 31 family.
UniProt Protein Details:

Protein type:EC 2.4.1.62; Glycan Metabolism - glycosphingolipid biosynthesis - ganglio series; Membrane protein, integral; Transferase

Chromosomal Location of Human Ortholog: 6p21.32

Molecular Function:UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity

NCBI Summary:This gene is a member of the beta-1,3-galactosyltransferase (beta3GalT) gene family. This family encodes type II membrane-bound glycoproteins with diverse enzymatic functions using different donor substrates (UDP-galactose and UDP-N-acetylglucosamine) and different acceptor sugars (N-acetylglucosamine, galactose, N-acetylgalactosamine). The beta3GalT genes are distantly related to the Drosophila Brainiac gene and have the protein coding sequence contained in a single exon. The beta3GalT proteins also contain conserved sequences not found in the beta4GalT or alpha3GalT proteins. The carbohydrate chains synthesized by these enzymes are designated as type 1, whereas beta4GalT enzymes synthesize type 2 carbohydrate chains. The ratio of type 1:type 2 chains changes during embryogenesis. By sequence similarity, the beta3GalT genes fall into at least two groups: beta3GalT4 and 4 other beta3GalT genes (beta3GalT1-3, beta3GalT5). This gene is oriented telomere to centromere in close proximity to the ribosomal protein S18 gene. The functionality of the encoded protein is limited to ganglioseries glycolipid biosynthesis. [provided by RefSeq, Jul 2008]
UniProt Code:O96024
NCBI GenInfo Identifier:4502341
NCBI Gene ID:8705
NCBI Accession:NP_003773.1
UniProt Related Accession:O96024
Molecular Weight:41.5
NCBI Full Name:beta-1,3-galactosyltransferase 4
NCBI Synonym Full Names:beta-1,3-galactosyltransferase 4
NCBI Official Symbol:B3GALT4  
NCBI Official Synonym Symbols:GALT2; GALT4; BETA3GALT4  
NCBI Protein Information:beta-1,3-galactosyltransferase 4
UniProt Protein Name:Beta-1,3-galactosyltransferase 4
UniProt Synonym Protein Names:Gal-T2; Ganglioside galactosyltransferase; UDP-galactose:beta-N-acetyl-galactosamine-beta-1,3-galactosyltransferase
Protein Family:Beta-1,3-galactosyltransferase
UniProt Gene Name:B3GALT4  
Anti-B3GALT4 Antibody (CAB15341)Western blot analysis of extracts of Mouse heart, using B3GALT4 antibody (CAB15341) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.

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