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Anti-Cadherin-11 Antibody (CAB8110)

SKU:
CAB8110
Product Type:
Antibody
Applications:
WB
IHC
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
  • Cell Biology Antibodies 11 Anti-Cadherin-11 Antibody CAB8110
  • Cell Biology Antibodies 11 Anti-Cadherin-11 Antibody CAB8110
€139 - €419
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Description

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Antibody Name:CDH11 Rabbit Polyclonal Antibody
Antibody SKU:CAB8110
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 637-796 of human CDH11 (NP_001788.2).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:U-87MG, A-549, HT-29, SKOV3, Mouse lung, Mouse spleen
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 637-796 of human CDH11 (NP_001788.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:FVTL RRQK KEPL IVFE EEDV RENI ITYD DEGG GEED TEAF DIAT LQNP DGIN GFIP RKDI KPEY QYMP RPGL RPAP NSVD VDDF INTR IQEA DNDP TAPP YDSI QIYG YEGR GSVA GSLS SLES ATTD SDLD YDYL QNWG PRFK KLAD LYGS KDTF DDDS
Gene ID:1009
Uniprot:P55287
Cellular Location:Cell membrane, Single-pass type I membrane protein
Calculated MW:76kDa/87kDa
Observed MW:120kDa
Synonyms:CDH11, CAD11, CDHOB, OB, OSF-4
Background:This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance.
UniProt Protein Function:CDH11: Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Interacts with PCDH8. Expressed mainly in brain but also found in other tissues. Expressed in neuroblasts. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Cell adhesion; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 16q21

Cellular Component: cytoplasm; integral to membrane; plasma membrane

Molecular Function:calcium ion binding

Biological Process: intercellular junction assembly and maintenance; ossification; corticospinal tract morphogenesis; homophilic cell adhesion; cell adhesion; skeletal development

UniProt Code:P55287
NCBI GenInfo Identifier:16306532
NCBI Gene ID:1009
NCBI Accession:NP_001788
UniProt Secondary Accession:P55287,Q15065, Q15066, Q9UQ93, Q9UQ94, A8K5D6, A8MZC8 B7WP28,
UniProt Related Accession:P55287
Molecular Weight:76,457 Da
NCBI Full Name:cadherin-11 preproprotein
NCBI Synonym Full Names:cadherin 11, type 2, OB-cadherin (osteoblast)
NCBI Official Symbol:CDH11  
NCBI Official Synonym Symbols:OB; CAD11; CDHOB; OSF-4  
NCBI Protein Information:cadherin-11
UniProt Protein Name:Cadherin-11
UniProt Synonym Protein Names:OSF-4; Osteoblast cadherin
Protein Family:Cadherin
UniProt Gene Name:CDH11  
UniProt Entry Name:CAD11_HUMAN
Anti-Cadherin-11 Polyclonal Antibody (CAB8110)Western blot analysis of extracts of various cell lines, using CDH11 antibody (CAB8110) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-Cadherin-11 Polyclonal Antibody (CAB8110)Immunohistochemistry of paraffin-embedded mouse brain using CDH11 antibody (CAB8110) at dilution of 1:100 (40x lens).

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