Anti-CCL26 Antibody (CAB7175)

Antibody Name:	Anti-CCL26 Antibody
Antibody SKU:	CAB7175
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IHC
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 24-94 of human CCL26 (NP_006063.1).

Application:	WB IHC
Recommended Dilution:	WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:	Human, Mouse, Rat
Positive Samples:	Mouse testis

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 24-94 of human CCL26 (NP_006063.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	TRGS DISK TCCF QYSH KPLP WTWV RSYE FTSN SCSQ RAVI FTTK RGKK VCTH PRKK WVQK YISL LKTP KQL
Gene ID:	10344
Uniprot:	Q9Y258
Cellular Location:	Secreted
Calculated MW:	10kDa
Observed MW:	11kDa

Synonyms:

CCL26, IMAC, MIP-4a, MIP-4alpha, SCYA26, TSC-1

Background:

This gene is one of two Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 7. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for normal peripheral blood eosinophils and basophils. The product of this gene is one of three related chemokines that specifically activate chemokine receptor CCR3. This chemokine may contribute to the eosinophil accumulation in atopic diseases.

UniProt Protein Function:	CCL26: Chemotactic for eosinophils and basophils. Binds to CCR3. Belongs to the intercrine beta (chemokine CC) family.
UniProt Protein Details:	Protein type:Chemokine; Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 7q11.23 Cellular Component: extracellular space Molecular Function:chemokine activity Biological Process: cell-cell signaling; positive regulation of actin filament polymerization; positive regulation of endothelial cell proliferation; immune response; chemotaxis; signal transduction; inflammatory response; positive regulation of cell migration
NCBI Summary:	This gene is one of two Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 7. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for normal peripheral blood eosinophils and basophils. The product of this gene is one of three related chemokines that specifically activate chemokine receptor CCR3. This chemokine may contribute to the eosinophil accumulation in atopic diseases. [provided by RefSeq, Jul 2008]
UniProt Code:	Q9Y258
NCBI GenInfo Identifier:	6685990
NCBI Gene ID:	10344
NCBI Accession:	Q9Y258.1
UniProt Secondary Accession:	Q9Y258,Q52LV8, A0N0Q5,
UniProt Related Accession:	Q9Y258
Molecular Weight:
NCBI Full Name:	C-C motif chemokine 26
NCBI Synonym Full Names:	chemokine (C-C motif) ligand 26
NCBI Official Symbol:	CCL26
NCBI Official Synonym Symbols:	IMAC; TSC-1; MIP-4a; SCYA26; MIP-4alpha
NCBI Protein Information:	C-C motif chemokine 26; eotaxin-3; MIP-4-alpha; chemokine N1; CC chemokine IMAC; thymic stroma chemokine-1; small inducible cytokine A26; small-inducible cytokine A26; macrophage inflammatory protein 4-alpha; small inducible cytokine subfamily A (Cys-Cys), member 26
UniProt Protein Name:	C-C motif chemokine 26
UniProt Synonym Protein Names:	CC chemokine IMAC; Eotaxin-3; Macrophage inflammatory protein 4-alpha; MIP-4-alpha; Small-inducible cytokine A26; Thymic stroma chemokine-1; TSC-1
Protein Family:	C-C motif chemokine
UniProt Gene Name:	CCL26
UniProt Entry Name:	CCL26_HUMAN

	Western blot analysis of extracts of mouse testis, using CCL26 antibody (CAB7175) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 90s.
	Immunohistochemistry of paraffin-embedded rat kidney using CCL26 antibody (CAB7175) at dilution of 1:200 (40x lens).
	Immunohistochemistry of paraffin-embedded human stomach using CCL26 antibody (CAB7175) at dilution of 1:200 (40x lens).
	Immunohistochemistry of paraffin-embedded mouse heart using CCL26 antibody (CAB7175) at dilution of 1:200 (40x lens).

Antibodies	ELISA Kits
Anti-CCL26 Antibody (CAB11980)	Human C-C motif chemokine 26 (CCL26) ELISA Kit
CCL26 Antibody (PACO01864)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)