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Anti-DUSP22 Antibody (CAB7281)

SKU:
CAB7281
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
  • Cell Biology Antibodies 11 Anti-DUSP22 Antibody CAB7281
  • Cell Biology Antibodies 11 Anti-DUSP22 Antibody CAB7281
€139 - €419
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Description

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Antibody Name:Anti-DUSP22 Antibody
Antibody SKU:CAB7281
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-184 of human DUSP22 (NP_064570.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:100
Reactivity:Human
Positive Samples:BT-474
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-184 of human DUSP22 (NP_064570.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MGNG MNKI LPGL YIGN FKDA RDAE QLSK NKVT HILS VHDS ARPM LEGV KYLC IPAA DSPS QNLT RHFK ESIK FIHE CRLR GESC LVHC LAGV SRSV TLVI AYIM TVTD FGWE DALH TVRA GRSC ANPN VGFQ RQLQ EFEK HEVH QYRQ WLKE EYGE SPLQ DAEE AKNI LAAP GILK FWAF LRRL
Gene ID:56940
Uniprot:Q9NRW4
Cellular Location:Cytoplasm, Nucleus
Calculated MW:20kDa/23kDa
Observed MW:21kDa
Synonyms:DUSP22, JKAP, JSP-1, JSP1, LMW-DSP2, LMWDSP2, MKP-x, MKPX, VHX
Background:
UniProt Protein Function:DUSP22: Activates the Jnk signaling pathway. Dephosphorylates and deactivates p38 and stress-activated protein kinase/c-Jun N- terminal kinase (SAPK/JNK). Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity; EC 3.1.3.48; EC 3.1.3.16; Apoptosis

Chromosomal Location of Human Ortholog: 6p25.3

Cellular Component: cytoplasm; nucleus

Molecular Function:protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity

Biological Process: cell proliferation; apoptosis; multicellular organismal development; transforming growth factor beta receptor signaling pathway; positive regulation of JNK cascade; negative regulation of transcription from RNA polymerase II promoter; protein amino acid dephosphorylation; inactivation of MAPK activity; regulation of cell proliferation

UniProt Code:Q9NRW4
NCBI GenInfo Identifier:74752929
NCBI Gene ID:56940
NCBI Accession:Q9NRW4.1
UniProt Secondary Accession:Q9NRW4,Q59GW2, Q5VWR2, Q96AR1, B4DK56,
UniProt Related Accession:Q9NRW4
Molecular Weight:184
NCBI Full Name:Dual specificity protein phosphatase 22
NCBI Synonym Full Names:dual specificity phosphatase 22
NCBI Official Symbol:DUSP22  
NCBI Official Synonym Symbols:VHX; JKAP; JSP1; MKPX; JSP-1; MKP-x; LMWDSP2; LMW-DSP2  
NCBI Protein Information:dual specificity protein phosphatase 22; MAP kinase phosphatase x; JNK-stimulating phosphatase 1; JNK-stimulatory phosphatase-1; mitogen-activated protein kinase phosphatase x; low molecular weight dual specificity phosphatase 2; homolog of mouse dual specificity phosphatase LMW-DSP2
UniProt Protein Name:Dual specificity protein phosphatase 22
UniProt Synonym Protein Names:JNK-stimulatory phosphatase-1; JSP-1; Low molecular weight dual specificity phosphatase 2; LMW-DSP2; Mitogen-activated protein kinase phosphatase x; MAP kinase phosphatase x; MKP-x
Protein Family:Dual specificity protein phosphatase
UniProt Gene Name:DUSP22  
UniProt Entry Name:DUS22_HUMAN
Anti-DUSP22 Antibody (CAB7281)Western blot analysis of extracts of BT-474 cells, using DUSP22 antibody (CAB7281) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 90s.
Anti-DUSP22 Antibody (CAB7281)Immunofluorescence analysis of A-549 cells using DUSP22 antibody (CAB7281). Blue: DAPI for nuclear staining.

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