ERBB2 Monoclonal Antibody [P7H3BV] (CPAB0104)
- SKU:
- CPAB0104
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Clone:
- P7H3BV
- Applications:
- WB
- ELISA
Frequently bought together:
Description
system_update_alt Datasheet
| Product Name: | ERBB2 Antibody |
| Product Sku: | CPAB0104 |
| Size: | 5μg |
| Host Species: | |
| Immunogen: | Anti-human ErbB2 mAb, is derived from mice immunized with the recombinant human ErbB2Â (43.4 kDa, 397Â a.aand one extra N-terminal Methionin)Â purified from Ecoli. |
| Clone: | P7H3BV. |
| Reactivity: | Human |
| Applications: | Western Blot, ELISA |
| Purification Method: | |
| Isotype: | |
| Background: | HER-2/neu (erbB-2) encodes an 185-kDa orphan receptor tyrosine kinase that is constitutively active as a dimer and displays potent oncogenic activity when overexpressed. Herstatin, as the product of alternative HER-2 transcript, retains intron 8. The herstatin mRNA is expressed in normal human fetal kidney and liver, but is at reduced levels relative to p185HER-2 mRNA in carcinoma cells that contain an amplified HER-2 gene. Herstatin appears to be an inhibitor of p185HER-2, because it disrupts dimers, reduces tyrosine phosphorylation of p185, and inhibits the anchorage-independent growth of transformed cells that overexpress HER-2. |
| Synonyms: | NEU, NGL, HER2, TKR1, HER-2, c-erb B2, HER-2/neu, Receptor tyrosine-protein kinase erbB-2, EC 2.7.10.1, p185erbB2, C-erbB-2, NEU proto-oncogene, Tyrosine kinase-type cell surface receptor HER2, MLN 19, CD340 antigen. |
| Storage Buffer: |
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