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[KO Validated] RB Rabbit Monoclonal Antibody (CAB3618)

SKU:
CAB3618
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Cycle
€139 - €419
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:[KO Validated] RB Rabbit Monoclonal Antibody
SKU:CAB3618
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 729-928 of human RB (P06400).
Sequence:KDLP HAVQ ETFK RVLI KEEE YDSI IVFY NSVF MQRL KTNI LQYA STRP PTLS PIPH IPRS PYKF PSSP LRIP GGNI YISP LKSP YKIS EGLP TPTK MTPR SRIL VSIG ESFG TSEK FQKI NQMV CNSD RVLK RSAE GSNP PKPL KKLR FDIE GSDE ADGS KHLP GESK FQQK LAEM TSTR TRMQ KQKM NDSM DTSN KEEK
Tested Applications:IF/ICC ELISA
Recommended Dilution:IF/ICC,1:50 - 1:200
Synonyms:RB; pRb; OSRC; pp110; p105-Rb; PPP1R130; p110-RB1
Positive Sample:U-2 OS
Conjugate:Unconjugated
Cellular Localization:Nucleus.
Calculated MW:106kDa
Observed MW:110kDa

The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.

Purification Method:Affinity purification
Gene ID:5925
Clone Number:ARC0810
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Product ImageConfocal imaging of U-2 OS cells using RB Rabbit mAb (A3618,dilution 1:100)(Red). The cells were counterstained with α-Tubulin Mouse mAb (AC012,dilution 1:400) (Green). DAPI was used for nuclear staining (blue). Objective: 100x.

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