PCNA Monoclonal Antibody [Pk1A3AT] (CPAB0525)
- SKU:
- CPAB0525
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Universal
- Host Species:
- Mouse
- Isotype:
- IgG3
- Clone:
- Pk1A3AT
- Applications:
- WB
- ELISA
Frequently bought together:
Description
system_update_alt Datasheet
| Product Name: | PCNA Antibody |
| Product Sku: | CPAB0525 |
| Size: | 5μg |
| Host Species: | Mouse |
| Immunogen: | Anti-human PCNA mAb is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with recombinant human PCNA amino acids 1-261 purified from Ecoli. |
| Clone: | Pk1A3AT. |
| Reactivity: | Other bodies |
| Applications: | Western Blot, ELISA |
| Purification Method: | PCNA antibody was purified from mouse ascitic fluids by protein-G affinity chromatography. |
| Isotype: | IgG3 |
| Background: | PCNA is located in the nucleus and is a cofactor of DNA polymerase delta. PCNA acts as a homotrimer and helps elevate the processivity of leading strand synthesis during DNA replication. In reaction to DNA damage, PCNA is ubiquitinated and takes part in the RAD6-dependent DNA repair pathway. 2 transcript variants encoding the same protein have been found for PCNA gene. Pseudogenes of this PCNA gene have been described on chromosome 4 and on the X chromosome. PCNA is expressed during late G1- phase, S-phase of mitosis and persists until the end of the M-phase because of its long biological half-life. PCNA is induced by UV irradiation. |
| Synonyms: | Proliferating cell nuclear antigen, PCNA, Cyclin, MGC8367. |
| Storage Buffer: | For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles. |
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