| UniProt Protein Function: | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents. |
| NCBI Summary: | This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014] |
| UniProt Code: | Q07343 |
| NCBI GenInfo Identifier: | 729163 |
| NCBI Gene ID: | 5142 |
| NCBI Accession: | Q07343.1 |
| UniProt Secondary Accession: | Q07343,O15443, Q13945, Q5TEK4, Q5TEK5, Q5TEK6, A5YW33 |
| UniProt Related Accession: | Q07343 |
| Molecular Weight: | 57,709 Da |
| NCBI Full Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4B |
| NCBI Synonym Full Names: | phosphodiesterase 4B |
| NCBI Official Symbol: | PDE4BÂ Â |
| NCBI Official Synonym Symbols: | DPDE4; PDEIVBÂ Â |
| NCBI Protein Information: | cAMP-specific 3',5'-cyclic phosphodiesterase 4B |
| UniProt Protein Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4B |
| UniProt Synonym Protein Names: | DPDE4; PDE32 |
| Protein Family: | cAMP-specific 3',5'-cyclic phosphodiesterase |
| UniProt Gene Name: | PDE4BÂ Â |
| UniProt Entry Name: | PDE4B_HUMAN |
