| UniProt Protein Function: | Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR. In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes. |
| NCBI Summary: | The OCT1 transcription factor was among the first identified members of the POU transcription factor family (summarized by Sturm et al., 1993 [PubMed 8314572]). Members of this family contain the POU domain, a 160-amino acid region necessary for DNA binding to the octameric sequence ATGCAAAT.[supplied by OMIM, Jul 2010] |
| UniProt Code: | P14859 |
| NCBI GenInfo Identifier: | 28202257 |
| NCBI Gene ID: | 5451 |
| NCBI Accession: | P14859.2 |
| UniProt Secondary Accession: | P14859,Q5TBT7, Q6PK46, Q8NEU9, Q9BPV1, B1AL91, B1AL93 B4E029, J3KP77, |
| UniProt Related Accession: | P14859 |
| Molecular Weight: | 72,082 Da |
| NCBI Full Name: | POU domain, class 2, transcription factor 1 |
| NCBI Synonym Full Names: | POU class 2 homeobox 1 |
| NCBI Official Symbol: | POU2F1Â Â |
| NCBI Official Synonym Symbols: | OCT1; OTF1; oct-1BÂ Â |
| NCBI Protein Information: | POU domain, class 2, transcription factor 1 |
| UniProt Protein Name: | POU domain, class 2, transcription factor 1 |
| UniProt Synonym Protein Names: | NF-A1; Octamer-binding protein 1; Oct-1; Octamer-binding transcription factor 1; OTF-1 |
| Protein Family: | POU domain, class 2, transcription factor |
| UniProt Gene Name: | POU2F1Â Â |
| UniProt Entry Name: | PO2F1_HUMAN |
