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Anti-PLA2G4D Antibody (CAB15224)

SKU:
CAB15224
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism
€139 - €419
Frequently bought together:

Description

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Antibody Name:Anti-PLA2G4D Antibody
Antibody SKU:CAB15224
Antibody Size:20uL, 50uL, 100uL
Application:IF
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 510-680 of human PLA2G4D (NP_828848.3).
Application:IF
Recommended Dilution:IF 1:50 - 1:200
Reactivity:Human
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 510-680 of human PLA2G4D (NP_828848.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:RLMR RIPE PRIC FLEA IWSN IFSL NLLD AWYD LTSS GESW KQHI KDKT RSLE KEPL TTSG TSSR LEAS WLQP GTAL AQAF KGFL TGRP LHQR SPNF LQGL QLHQ DYCS HKDF STWA DYQL DSMP SQLT PKEP RLCL VDAA YFIN TSSP SMFR PGRR LDLI LSFD YSLS APF
Gene ID:283748
Uniprot:Q86XP0
Cellular Location:Cytoplasm, Cytoplasmic side, Cytoplasmic vesicle membrane, Peripheral membrane protein, cytosol
Calculated MW:80kDa/91kDa
Observed MW:
Synonyms:PLA2G4D, cPLA2delta
Background:
UniProt Protein Function:PLA2G4D: a calcium-dependent phospholipase A2 that catalyzes the release of arachidonic acid from membrane phospholipids. Selectively hydrolyzes glycerophospholipids in the sn-2 position. Not arachidonic acid-specific but has linoleic acid-specific activity. May play a role in inflammation in psoriatic lesions. Expressed in stratified squamous epithelia, such as those in skin and cervix, but not in other tissues. Strongly expressed in the upper spinous layer of the psoriatic epidermis, expressed weakly and discontinuously in atopic dermatitis and mycosis fungoides, and not detected in the epidermis of normal skin. The N-terminal C2 domain associates with lipid membranes and mediates its regulation by presenting the active site to its substrate in response to elevations of cytosolic Ca2+. Two isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 3.1.1.4; Phospholipase; Lipid Metabolism - arachidonic acid

Chromosomal Location of Human Ortholog: 15q15.1

Cellular Component: cytosol

Molecular Function:lysophospholipase activity; phospholipase A1 activity; phospholipase A2 activity

Biological Process: phosphatidic acid biosynthetic process; phospholipid metabolic process

NCBI Summary:The phospholipase A2 enzyme family, including PLA2G4D, catalyze the hydrolysis of glycerophospholipids at the sn-2 position and then liberate free fatty acids and lysophospholipids (Chiba et al., 2004 [PubMed 14709560]).[supplied by OMIM, Jun 2009]
UniProt Code:Q86XP0
NCBI GenInfo Identifier:269849641
NCBI Gene ID:283748
NCBI Accession:Q86XP0.2
UniProt Secondary Accession:Q86XP0,Q8N176,
UniProt Related Accession:Q86XP0
Molecular Weight:80,930 Da
NCBI Full Name:Cytosolic phospholipase A2 delta
NCBI Synonym Full Names:phospholipase A2 group IVD
NCBI Official Symbol:PLA2G4D  
NCBI Official Synonym Symbols:cPLA2delta  
NCBI Protein Information:cytosolic phospholipase A2 delta
UniProt Protein Name:Cytosolic phospholipase A2 delta
UniProt Synonym Protein Names:Phospholipase A2 group IVD
Protein Family:Cytosolic phospholipase
UniProt Gene Name:PLA2G4D  
UniProt Entry Name:PA24D_HUMAN
Anti-PLA2G4D Antibody (CAB15224)Immunofluorescence analysis of Hela cells using PLA2G4D antibody (CAB15224) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.

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