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Recombinant HER2 Monoclonal Antibody (CPAB0212)

SKU:
CPAB0212
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
€149
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Description

system_update_alt Datasheet
Product Name:Recombinant HER2 Antibody
Product Sku:CPAB0212
Size:1mg
Host Species:
Immunogen:
Clone:
Reactivity:Human
Applications:
Purification Method:
Isotype:
Background:HER-2/neu (erbB-2) encodes an 185-kDa orphan receptor tyrosine kinase that is constitutively active as a dimer and displays potent oncogenic activity when overexpressed. Herstatin, as the product of alternative HER-2 transcript, retains intron 8. The herstatin mRNA is expressed in normal human fetal kidney and liver, but is at reduced levels relative to p185HER-2 mRNA in carcinoma cells that contain an amplified HER-2 gene. Herstatin appears to be an inhibitor of p185HER-2, because it disrupts dimers, reduces tyrosine phosphorylation of p185, and inhibits the anchorage-independent growth of transformed cells that overexpress HER-2.
Synonyms:
Storage Buffer:

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