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Anti-ADGRB3 Antibody (CAB11956)

SKU:
CAB11956
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
€139 - €419
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Description

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Antibody Name:Anti-ADGRB3 Antibody
Antibody SKU:CAB11956
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 70-280 of human ADGRB3 (NP_001695.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:293T
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 70-280 of human ADGRB3 (NP_001695.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:YLKF SKKD LSCS NFSL LAYQ FDHF SHEK IKDL LRKN HSIM QLCN SKNA FVFL QYDK NFIQ IRRV FPTN FPGL QKKG EEDQ KSFF EFLV LNKV SPSQ FGCH VLCT WLES CLKS ENGR TESC GIMY TKCT CPQH LGEW GIDD QSLI LLNN VVLP LNEQ TEGC LTQE LQTT QVCN LTRE AKRP PKEE FGMM GDHT IKSQ RPRS VHEK RVPQ EQA
Gene ID:577
Uniprot:O60242
Cellular Location:Cell membrane, Multi-pass membrane protein
Calculated MW:55kDa/171kDa
Observed MW:180kDa
Synonyms:ADGRB3, BAI3
Background:This p53-target gene encodes a brain-specific angiogenesis inhibitor, a seven-span transmembrane protein, and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities, and may also play a role in angiogenesis.
UniProt Protein Function:BAI3: May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses. Might be involved in angiogenesis inhibition and suppression of glioblastoma. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
UniProt Protein Details:

Protein type:GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 6q12-q13

Cellular Component: plasma membrane

Molecular Function:GTPase activator activity; protein binding

Biological Process: myoblast fusion; regulation of dendrite morphogenesis

NCBI Summary:This p53-target gene encodes a brain-specific angiogenesis inhibitor, a seven-span transmembrane protein, and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities, and may also play a role in angiogenesis. [provided by RefSeq, Jul 2008]
UniProt Code:O60242
NCBI GenInfo Identifier:311033353
NCBI Gene ID:577
NCBI Accession:O60242.2
UniProt Secondary Accession:O60242,O60297, Q2NKN6, Q5VY37, Q9BX54, B7Z1K0,
UniProt Related Accession:O60242
Molecular Weight:172kDa
NCBI Full Name:Adhesion G protein-coupled receptor B3
NCBI Synonym Full Names:adhesion G protein-coupled receptor B3
NCBI Official Symbol:ADGRB3  
NCBI Official Synonym Symbols:BAI3  
NCBI Protein Information:adhesion G protein-coupled receptor B3
UniProt Protein Name:Adhesion G protein-coupled receptor B3
UniProt Synonym Protein Names:Brain-specific angiogenesis inhibitor 3
Protein Family:Adhesion G protein-coupled receptor
UniProt Gene Name:ADGRB3  
Anti-ADGRB3 Antibody (CAB11956)Western blot analysis of extracts of 293T cells, using ADGRB3 antibody (CAB11956) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.

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