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Anti-AZIN1 Antibody (CAB4747)

SKU:
CAB4747
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
AZIN1
AZI
AZI1
AZIA1
OAZI
OAZIN
ODC1L
Research Area:
Metabolism
  • Metabolism Antibodies 2 Anti-AZIN1 Antibody CAB4747
  • Metabolism Antibodies 2 Anti-AZIN1 Antibody CAB4747
€139 - €419
Frequently bought together:

Description

Product Name:AZIN1 Rabbit pAb
Product Code:CAB4747
Size:20uL, 50uL, 100uL
Synonyms:AZIN1, AZI, AZI1, AZIA1, OAZI, OAZIN, ODC1L
Applications:WB, IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 289-448 of human AZIN1 (NP_056962.2).
Applications:WB, IHC
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:HepG2, Mouse thymus, Rat thymus
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 289-448 of human AZIN1 (NP_056962.2).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:AKKV VEND KFPS GVEK TGSD EPAF MYYM NDGV YGSF ASKL SEDL NTIP EVHK KYKE DEPL FTSS LWGP SCDE LDQI VESC LLPE LNVG DWLI FDNM GADS FHEP SAFN DFQR PAIY YMMS FSDW YEMQ DAGI TSDS MMKN FFFV PSCI QLSQ EDSF SAEA
Gene ID:51582
Uniprot:O14977
Cellular Location:Nucleus
Calculated MW:49kDa
Observed MW:49kDa
UniProt Protein Function:AZIN1: Regulates cellular polyamine homeostasis. Inhibits antizyme-dependent ornithine decarboxylase degradation by binding to antizyme. Belongs to the Orn/Lys/Arg decarboxylase class-II family. ODC antizyme inhibitor subfamily.
UniProt Protein Details:

Protein type:Inhibitor

Chromosomal Location of Human Ortholog: 8q22.3

Cellular Component: nucleus; cytosol

Molecular Function:enzyme inhibitor activity; ornithine decarboxylase activator activity; catalytic activity

Biological Process: positive regulation of catalytic activity; polyamine biosynthetic process; negative regulation of catalytic activity; regulation of amino acid metabolic process; negative regulation of protein catabolic process

NCBI Summary:The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 1, the first member of this gene family that is ubiquitously expressed, and is localized in the nucleus and cytoplasm. Overexpression of antizyme inhibitor 1 gene has been associated with increased proliferation, cellular transformation and tumorigenesis. Gene knockout studies showed that homozygous mutant mice lacking functional antizyme inhibitor 1 gene died at birth with abnormal liver morphology. RNA editing of this gene, predominantly in the liver tissue, has been linked to the progression of hepatocellular carcinoma. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2014]
UniProt Code:O14977
NCBI GenInfo Identifier:33860187
NCBI Gene ID:51582
NCBI Accession:O14977.2
UniProt Secondary Accession:O14977,Q6IBQ7, Q96D20, A6NCD5,
UniProt Related Accession:O14977
Molecular Weight:49,535 Da
NCBI Full Name:Antizyme inhibitor 1
NCBI Synonym Full Names:antizyme inhibitor 1
NCBI Official Symbol:AZIN1  
NCBI Official Synonym Symbols:AZI; OAZI; AZIA1; OAZIN; ODC1L  
NCBI Protein Information:antizyme inhibitor 1; ornithine decarboxylase antizyme inhibitor
UniProt Protein Name:Antizyme inhibitor 1
UniProt Synonym Protein Names:Ornithine decarboxylase antizyme inhibitor
Protein Family:Antizyme inhibitor
UniProt Gene Name:AZIN1  
UniProt Entry Name:AZIN1_HUMAN

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