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Anti-Carboxypeptidase Q Antibody (CAB8478)

SKU:
CAB8478
Product Type:
Antibody
Applications:
WB
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
€139 - €419
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Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-Carboxypeptidase Q Antibody
Antibody SKU:CAB8478
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 20-200 of human CPQ (NP_057218.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse
Positive Samples:Mouse liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 20-200 of human CPQ (NP_057218.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:GKAI CKNG ISKR TFEE IKEE IASC GDVA KAII NLAV YGKA QNRS YERL ALLV DTVG PRLS GSKN LEKA IQIM YQNL QQDG LEKV HLEP VRIP HWER GEES AVML EPRI HKIA ILGL GSSI GTPP EGIT AEVL VVTS FDEL QRRA SEAR GKIV VYNQ PYIN YSRT VQYR TQGA VEAA KVGA L
Gene ID:10404
Uniprot:Q9Y646
Cellular Location:Endoplasmic reticulum, Golgi apparatus, Lysosome, Secreted
Calculated MW:51kDa
Observed MW:60kDa
Synonyms:CPQ, LDP, PGCP
Background:This gene encodes a metallopeptidase that belongs to the peptidase M28 family. The encoded protein may catalyze the cleavage of dipeptides with unsubstituted terminals into amino acids.
UniProt Protein Function:PGCP: Carboxypeptidase that may play an important role in the hydrolysis of circulating peptides. Catalyzes more efficiently the hydrolysis of dipeptides with unsubstituted terminals into amino acids. May play a role in thyroxin hormone liberation from its TG/thyroglobulin precursor. Belongs to the peptidase M28 family.
UniProt Protein Details:

Protein type:EC 3.4.17.-; Protease; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 8q22.1

Cellular Component: cytoplasm; endoplasmic reticulum; extracellular space; Golgi apparatus; lysosome

Molecular Function:protein homodimerization activity

Biological Process: peptide catabolic process; proteolysis; thyroid hormone generation; tissue regeneration

NCBI Summary:This gene encodes a metallopeptidase that belongs to the peptidase M28 family. The encoded protein may catalyze the cleavage of dipeptides with unsubstituted terminals into amino acids. [provided by RefSeq, Jul 2013]
UniProt Code:Q9Y646
NCBI GenInfo Identifier:74735298
NCBI Gene ID:10404
NCBI Accession:Q9Y646.1
UniProt Secondary Accession:Q9Y646,Q8NBZ1, Q9UNM8, Q9Y5X6, B2RD88,
UniProt Related Accession:Q9Y646
Molecular Weight:52kDa
NCBI Full Name:Carboxypeptidase Q
NCBI Synonym Full Names:carboxypeptidase Q
NCBI Official Symbol:CPQ  
NCBI Official Synonym Symbols:LDP; PGCP  
NCBI Protein Information:carboxypeptidase Q
UniProt Protein Name:Carboxypeptidase Q
UniProt Synonym Protein Names:Lysosomal dipeptidase; Plasma glutamate carboxypeptidase
Protein Family:Carboxypeptidase
UniProt Gene Name:CPQ  
Anti-Carboxypeptidase Q Polyclonal Antibody (CAB8478)Western blot analysis of extracts of mouse liver, using CPQ antibody (CAB8478) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.

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